Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 14/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16655174 | 0.82 | FGFR3 (0.38) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL16654740 | 0.79 | FGFR4 (0.48) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL17740814 | 0.68 | FGFR4 (0.49) | FGFR4FGFR1FGFR3FGFR2 | |
| SCHEMBL16659545 | 0.64 | FGFR1 (0.52) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL17740813 | 0.64 | FGFR4 (0.65) | FGFR4FGFR1FGFR3FGFR2 | |
| SCHEMBL16659404 | 0.64 | FGFR1 (0.58) | FGFR4FGFR1FGFR3FGFR2 | |
| SCHEMBL28767438 | 0.63 | FGFR3 (0.42) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL16665301 | 0.62 | FGFR1 (0.55) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL16655080 | 0.61 | FGFR1 (0.50) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL16654074 | 0.60 | FGFR1 (0.75) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057943-A1 | PYRIMIDINE FGFR4 INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |