Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 16/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16659545 | 0.92 | FGFR1 (0.52) | FGFR1FGFR3CYP3A4CYP2C19FGFR4 | |
| SCHEMBL16655080 | 0.88 | FGFR1 (0.50) | FGFR1FGFR3CYP3A4CYP2C19FGFR4 | |
| SCHEMBL17740814 | 0.84 | FGFR4 (0.49) | FGFR1FGFR3FGFR4FGFR2 | |
| SCHEMBL16654740 | 0.82 | FGFR4 (0.48) | FGFR1FGFR3CYP3A4CYP2C19FGFR4 | |
| SCHEMBL17740813 | 0.80 | FGFR4 (0.65) | FGFR1FGFR3FGFR4FGFR2 | |
| SCHEMBL28767438 | 0.80 | FGFR3 (0.42) | FGFR1FGFR3CYP3A4CYP2C19FGFR4 | |
| SCHEMBL18153622 | 0.80 | FGFR1 (0.57) | FGFR1FGFR3FGFR4FGFR2 | |
| SCHEMBL16654119 | 0.78 | FGFR3 (0.35) | FGFR1FGFR3CYP3A4CYP2C19FGFR4 | |
| SCHEMBL18153620 | 0.77 | FGFR1 (0.73) | FGFR1FGFR3FGFR4FGFR2 | |
| SCHEMBL28768907 | 0.77 | FGFR3 (0.40) | FGFR1FGFR3CYP3A4CYP2C19FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |