Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 9/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | INSR | P06213 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | YES1 | P07947 | 2/20 | 0.34 |
| ▸ | LYN | P07948 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | ROS1 | P08922 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16654119 | 0.69 | FGFR3 (0.35) | FGFR3CYP3A4CYP2C19FGFR4CYP2C9 | |
| SCHEMBL28767438 | 0.69 | FGFR3 (0.42) | FGFR3CYP3A4CYP2C19FGFR4CYP2C9 | |
| SCHEMBL28768907 | 0.68 | FGFR3 (0.40) | FGFR3CYP3A4CYP2C19FGFR4CYP2C9 | |
| SCHEMBL16654403 | 0.67 | FGFR4 (0.41) | FGFR3CYP3A4CYP2C19FGFR4FGFR1 | |
| SCHEMBL16655847 | 0.67 | FGFR4 (0.42) | FGFR3CYP3A4CYP2C19FGFR4FGFR1 | |
| SCHEMBL16665253 | 0.67 | FGFR1 (0.33) | FGFR3CYP3A4CYP2C19FGFR4FGFR1 | |
| SCHEMBL20610863 | 0.65 | — | — | |
| SCHEMBL16655835 | 0.65 | FGFR3 (0.33) | FGFR3CYP3A4CYP2C19FGFR4FGFR1 | |
| SCHEMBL16655790 | 0.65 | FGFR1 (0.44) | FGFR1 | |
| SCHEMBL21508686 | 0.63 | L3MBTL1 (0.50) | FGFR4FGFR1JAK2TYK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057943-A1 | PYRIMIDINE FGFR4 INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |