SCHEMBL16656166

SCHEMBL16656166

Cc1ccccc1N1C(=O)c2ccc3c4c(ccc(c24)C1=O)C(=O)N(C)C3=O

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.66
MEN1 O00255 7/20 0.66
CASP3 P42574 3/20 0.50
MGLL Q99685 1/20 0.50
CASP6 P55212 1/20 0.50
SENP8 Q96LD8 1/20 0.50
SENP7 Q9BQF6 1/20 0.50
SENP6 Q9GZR1 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
MAPT P10636 4/20 0.49
ALDH1A1 P00352 4/20 0.49
USP2 O75604 2/20 0.49
GAA P10253 1/20 0.49
CRHBP P24387 1/20 0.49
CASP1 P29466 1/20 0.49
BRCA1 P38398 1/20 0.49
CASP7 P55210 1/20 0.49
HBB P68871 1/20 0.49
CRHR2 Q13324 1/20 0.49
HSD17B10 Q99714 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13084694 0.93 KMT2A (0.74) KMT2AMEN1CASP3MGLLCASP6
SCHEMBL30777592 0.81 KMT2A (0.73) KMT2AMEN1CASP3MGLLCASP6
SCHEMBL29379598 0.81 KMT2A (0.73) KMT2AMEN1CASP3MGLLCASP6
SCHEMBL30758615 0.81 KMT2A (0.73) KMT2AMEN1CASP3MGLLCASP6
SCHEMBL2550815 0.81 KMT2A (0.73) KMT2AMEN1CASP3MGLLCASP6
SCHEMBL85774 0.79 APEX1 (0.61) KMT2AMEN1ALDH1A1HSD17B10POLB
SCHEMBL2924935 0.79 KMT2A (0.60) KMT2AMEN1CASP3CASP6SENP8
SCHEMBL13084665 0.79 KMT2A (0.60) KMT2AMEN1CASP3MGLLCASP6
SCHEMBL28460775 0.78 KMT2A (0.64) KMT2AMEN1CASP3MGLLCASP6
SCHEMBL30937815 0.77 MEN1 (0.55) KMT2AMEN1CASP3MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9012112-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-04-21 US disclosed