Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.56 |
| ▸ | RAB9A | P51151 | 8/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | MITF | O75030 | 2/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.56 |
| ▸ | KDM5A | P29375 | 1/20 | 0.56 |
| ▸ | KDM5C | P41229 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22614984 | 0.87 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| Bromide SCHEMBL1691891 | 0.85 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2544254 | 0.84 | RAB9A (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1395044 | 0.84 | DRD2 (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2540879 | 0.84 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL3108835 | 0.83 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL10533395 | 0.82 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1743706 | 0.82 | DYRK1A (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL19327435 | 0.81 | HDAC6 (0.52) | NPC1RAB9AALDH1A1KDM4EKMT2A | |
| SCHEMBL4921911 | 0.80 | APP (0.41) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891042-B1 | 2-OXO-1-PYRROLIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR THERAPEUTIC USE ON THE CENTRAL NERVOUS SYSTEM | UCB PHARMA SA (BE) | 2013-10-02 | — | — | EP | disclosed |
| EP-2308870-A2 | 2-oxo-1-pyrrolidine deriatives, processes for preparing them and their uses | UCB Pharma S.A. (BE) | 2011-04-13 | — | — | EP | disclosed |
| EP-2308867-A2 | 2-oxo-1-pyrrolidine deriatives, processes for preparing them and their uses | UCB Pharma S.A. (BE) | 2011-04-13 | — | — | EP | disclosed |