Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.70 |
| ▸ | HPGD | P15428 | 8/20 | 0.70 |
| ▸ | CASP1 | P29466 | 3/20 | 0.70 |
| ▸ | CASP7 | P55210 | 3/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.70 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.57 |
| ▸ | GLA | P06280 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | USP2 | O75604 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HBB | P68871 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16658645 | 0.99 | KDM4E (0.68) | ALDH1A1KDM4EHPGDCASP1CASP7 | |
| SCHEMBL16658646 | 0.91 | HSD17B10 (0.60) | ALDH1A1KDM4EHPGDCASP1CASP7 | |
| SCHEMBL16623049 | 0.91 | KDM4E (0.58) | ALDH1A1KDM4EHPGDCASP1CASP7 | |
| SCHEMBL16658642 | 0.89 | KDM4E (0.56) | ALDH1A1KDM4EHPGDCASP1CASP7 | |
| SCHEMBL16623035 | 0.88 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDCASP1CASP7 | |
| SCHEMBL16658659 | 0.88 | KDM4E (0.61) | ALDH1A1KDM4EHPGDCASP1CASP7 | |
| SCHEMBL16623038 | 0.87 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDCASP1CASP7 | |
| SCHEMBL16623042 | 0.87 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDCASP1CASP7 | |
| SCHEMBL16658653 | 0.86 | KDM4E (0.55) | ALDH1A1KDM4EHPGDCASP1CASP7 | |
| SCHEMBL16623033 | 0.86 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDCASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9630953-B2 | Small compounds targeting TACC3 | JAPANESE FOUNDATION FOR CANCER RESEARCH (JP) | 2017-04-25 | — | — | US | disclosed |
| US-9630953-B2 | Small compounds targeting TACC3 | JAPANESE FOUNDATION FOR CANCER RESEARCH (JP) | 2017-04-25 | — | — | US | disclosed |
| US-20150111888-A1 | SMALL COMPOUNDS TARGETING TACC3 | JAPANESE FOUNDATION FOR CANCER RESEARCH (JP) | 2015-04-23 | — | — | US | disclosed |
| US-20150111888-A1 | SMALL COMPOUNDS TARGETING TACC3 | JAPANESE FOUNDATION FOR CANCER RESEARCH (JP) | 2015-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111888-A1 | SMALL COMPOUNDS TARGETING TACC3 | TACR3, TACR2, SLC43A1 | ALDH1A1 2396/4885KDM4E 3171/4885HPGD 4170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.