Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23838607 | 0.93 | KMT2A (0.54) | KMT2ANPC1MEN1RAB9ATDP1 | |
| SCHEMBL16730658 | 0.88 | MAPT (0.49) | KMT2ANPC1MEN1RAB9ATDP1 | |
| SCHEMBL16644147 | 0.80 | NPC1 (0.55) | KMT2ANPC1MEN1RAB9ATDP1 | |
| SCHEMBL16644172 | 0.77 | NQO2 (0.46) | KMT2ANPC1MEN1RAB9ATDP1 | |
| SCHEMBL16646641 | 0.75 | ALDH1A1 (0.47) | KMT2ANPC1MEN1RAB9ATDP1 | |
| SCHEMBL30645370 | 0.73 | KMT2A (0.50) | KMT2ANPC1MEN1RAB9ATDP1 | |
| SCHEMBL16646581 | 0.73 | KMT2A (0.50) | KMT2ANPC1MEN1RAB9ATDP1 | |
| SCHEMBL24541019 | 0.73 | NPC1 (0.50) | KMT2ANPC1MEN1RAB9ATDP1 | |
| SCHEMBL19622430 | 0.71 | TDP1 (0.70) | KMT2ANPC1MEN1RAB9ATDP1 | |
| SCHEMBL23838593 | 0.70 | NPC1 (0.46) | KMT2ANPC1MEN1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057876-A1 | DRUG-CONJUGATES WITH A TARGETING MOLECULE AND TWO DIFFERENT DRUGS | SORRENTO THERAPEUTICS INC. (US) | 2015-04-23 | — | — | WO | disclosed |