Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24541019 | 0.76 | NPC1 (0.50) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL16730658 | 0.74 | MAPT (0.49) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL16646641 | 0.72 | ALDH1A1 (0.47) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL24584905 | 0.72 | NPC1 (0.50) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL24584368 | 0.72 | NQO2 (0.57) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL18945680 | 0.70 | TDP1 (0.38) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL16660774 | 0.70 | KMT2A (0.48) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL20048900 | 0.68 | LRRK2 (0.37) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL14607882 | 0.67 | ENPP2 (0.50) | NPC1RAB9ATDP1ALDH1A1MAPT | |
| SCHEMBL9823025 | 0.67 | NPC1 (0.75) | NPC1RAB9AMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057610-B1 | DRUG-CONJUGATES WITH A TARGETING MOLECULE AND TWO DIFFERENT DRUGS | SORRENTO THERAPEUTICS INC (US) | 2021-09-22 | — | — | EP | disclosed |