SCHEMBL16664372

SCHEMBL16664372

C=Nc1cccc(OC(F)(F)F)c1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MPI P34949 1/20 0.49
SYK P43405 1/20 0.41
SLC22A12 Q96S37 1/20 0.39
XDH P47989 1/20 0.39
GPR3 P46089 2/20 0.39
EPHX2 P34913 1/20 0.38
ALDH1A1 P00352 1/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
TSHR P16473 1/20 0.38
HTT P42858 1/20 0.38
KCNH2 Q12809 1/20 0.38
SCN10A Q9Y5Y9 1/20 0.38
CTSC P53634 1/20 0.38
KIF11 P52732 2/20 0.38
CETP P11597 1/20 0.38
P2RX1 P51575 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28167311 0.81 MPI (0.49) MPISLC22A12XDHGPR3EPHX2
SCHEMBL3147185 0.79 GPR3 (0.50) MPISLC22A12XDHGPR3EPHX2
SCHEMBL29795880 0.77 MPI (0.46) MPISLC22A12XDHALDH1A1GAA
SCHEMBL22042114 0.77 MPI (0.46) MPISYKSLC22A12GPR3EPHX2
SCHEMBL1089262 0.77 MPI (0.46) MPISLC22A12XDHALDH1A1GAA
SCHEMBL6699663 0.77 MPI (0.46) MPISYKSLC22A12GPR3EPHX2
SCHEMBL29717662 0.77 MPI (0.46) MPISYKSLC22A12GPR3EPHX2
SCHEMBL16846314 0.75 NOS3 (0.45) GPR3EPHX2ALDH1A1MAPTALOX15
SCHEMBL20657404 0.74 MPI (0.44) MPIALDH1A1GAAMAPTHPGD
SCHEMBL3463063 0.74 CA12 (0.50) MPISYKXDHEPHX2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2376489-B1 ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF CHIESI FARMA SPA (IT) 2015-04-22 EP disclosed