SCHEMBL16664772

SCHEMBL16664772

CC(C)(C)OC(=O)CCNCCC=O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.37
HDAC3 O15379 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
CTSK P43235 3/20 0.35
CYP2D6 P10635 1/20 0.35
EPHX2 P34913 1/20 0.35
MLYCD O95822 1/20 0.34
TDP1 Q9NUW8 1/20 0.33
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
DGAT1 O75907 1/20 0.31
MEN1 O00255 1/20 0.31
GAA P10253 1/20 0.31
KMT2A Q03164 1/20 0.31
EPHX1 P07099 1/20 0.30
CA12 O43570 2/20 0.30
CA2 P00918 2/20 0.30
CA14 Q9ULX7 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3485766 0.88 EPHX2 (0.40) HDAC6HDAC3HDAC1HDAC2HDAC8
SCHEMBL7505726 0.83 CTSK (0.36) HDAC6HDAC3HDAC1HDAC2HDAC8
SCHEMBL4583910 0.82 HDAC6 (0.42) HDAC6HDAC3HDAC1HDAC2HDAC8
SCHEMBL9201782 0.81 TSHR (0.38) CTSKCYP2D6EPHX2MLYCDTDP1
SCHEMBL948359 0.81 PAOX (0.38) HDAC6HDAC3HDAC1HDAC2HDAC8
SCHEMBL6191373 0.81 TDP1 (0.42) HDAC6HDAC3HDAC1HDAC2HDAC8
SCHEMBL308857 0.81 EPHX2 (0.39) HDAC6HDAC3HDAC1HDAC2HDAC8
Hydrochloric Acid SCHEMBL30639492 0.80 HDAC6 (0.41) HDAC6HDAC3HDAC1HDAC2HDAC8
SCHEMBL3664095 0.80 TDP1 (0.50) CTSKCYP2D6TDP1MAOAMAOB
SCHEMBL10250750 0.79 EPHX2 (0.35) HDAC6HDAC3HDAC1HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1289565-B1 COMPOUNDS FOR TARGETING ENDOTHELIAL CELLS BRACCO SUISSE SA (CH) 2015-04-22 EP disclosed