Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 11/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15356561 | 0.87 | HRH4 (0.47) | HRH4HCAR3HCAR2FAAHKDM4E | |
| SCHEMBL15343309 | 0.86 | HCAR3 (0.47) | HRH4HCAR3HCAR2FAAHKDM4E | |
| SCHEMBL15473138 | 0.86 | KDM4E (0.49) | HRH4HCAR3HCAR2FAAHKDM4E | |
| SCHEMBL17634509 | 0.82 | CYP1A2 (0.46) | HRH4FAAHKDM4EMAPK1 | |
| SCHEMBL15343196 | 0.82 | CYP1A2 (0.46) | HRH4FAAHKDM4EMAPK1 | |
| SCHEMBL19355338 | 0.81 | CYP1A2 (0.50) | FAAHKDM4EMAPK1 | |
| SCHEMBL15343250 | 0.81 | CYP1A2 (0.50) | HRH4FAAHKDM4EMAPTPIK3CA | |
| SCHEMBL15473117 | 0.81 | HRH4 (0.41) | HRH4FAAHKDM4EPOLBMAPT | |
| SCHEMBL16660261 | 0.80 | PIK3CA (0.46) | HRH4HCAR3HCAR2FAAHPDE10A | |
| SCHEMBL17634573 | 0.79 | PRKDC (0.45) | HRH4FAAHKDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015058031-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-04-23 | — | — | WO | disclosed |