Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 10/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15343309 | 0.83 | HCAR3 (0.47) | PIK3CAFAAHHCAR3HCAR2HRH4 | |
| SCHEMBL15343250 | 0.80 | CYP1A2 (0.50) | PIK3CAFAAHHRH4CYP1A2CYP3A4 | |
| SCHEMBL16664920 | 0.80 | HRH4 (0.50) | PIK3CAFAAHHCAR3HCAR2HRH4 | |
| SCHEMBL15343251 | 0.79 | PRKDC (0.40) | PIK3CAFAAHCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16664942 | 0.78 | SYK (0.49) | PIK3CAHRH4 | |
| SCHEMBL15343079 | 0.78 | PIK3CA (0.44) | PIK3CAFAAHHRH4 | |
| SCHEMBL16664972 | 0.78 | PIK3CA (0.44) | PIK3CAFAAHHRH4CYP1A2CYP3A4 | |
| SCHEMBL15473138 | 0.78 | KDM4E (0.49) | PIK3CAFAAHHCAR3HCAR2HRH4 | |
| SCHEMBL17634550 | 0.77 | PDE10A (0.40) | PIK3CAFAAHCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15356561 | 0.77 | HRH4 (0.47) | PIK3CAFAAHHCAR3HCAR2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150111871-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111871-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | PIK3CA 226/4885FAAH 3955/4885HCAR3 4144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.