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Sugi Predict / Compounds / SCHEMBL16665233

SCHEMBL16665233

SCHEMBL16665233

C=CC(=O)Nc1cc(COCC)ccc1N(C(=O)OC(C)(C)C)c1cc(N(C)C(=O)N(C(=O)OC(C)(C)C)c2c(Cl)c(OC)cc(OC)c2Cl)ncn1

nearest known ligand 0.48

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 15/20 0.48
▸ FGFR2 P21802 2/20 0.42
▸ FGFR3 P22607 2/20 0.42
▸ FGFR4 P22455 5/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17736233 0.91 FGFR1 (0.47) FGFR1FGFR2FGFR3FGFR4
SCHEMBL17740761 0.88 FGFR1 (0.46) FGFR1FGFR2FGFR3FGFR4
SCHEMBL16659420 0.87 FGFR1 (0.33) FGFR1FGFR2FGFR3FGFR4
SCHEMBL17736227 0.86 FGFR1 (0.49) FGFR1FGFR2FGFR3FGFR4
SCHEMBL16659423 0.84 FGFR1 (0.32) FGFR1FGFR2FGFR3FGFR4
SCHEMBL16658529 0.82 FGFR1 (0.46) FGFR1FGFR2FGFR3FGFR4
SCHEMBL17736239 0.82 FGFR1 (0.58) FGFR1FGFR2FGFR3FGFR4
SCHEMBL19633462 0.82 FGFR1 (0.59) FGFR1FGFR2FGFR3FGFR4
SCHEMBL19633583 0.82 FGFR1 (0.59) FGFR1FGFR2FGFR3FGFR4
SCHEMBL19633347 0.81 FGFR1 (0.61) FGFR1FGFR2FGFR3FGFR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015057963-A1 FGFR4 INHIBITORS EISAI R&D MANAGEMENT CO., LTD. (JP) 2015-04-23 — — WO disclosed
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