Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | YES1 | P07947 | 1/20 | 0.30 |
| ▸ | LYN | P07948 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
| ▸ | ROS1 | P08922 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | BCR | P11274 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665243 | 0.92 | FGFR1 (0.36) | FGFR1FGFR3CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL17736229 | 0.90 | FGFR1 (0.31) | FGFR1FGFR3CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL16659420 | 0.89 | FGFR1 (0.33) | FGFR1FGFR3CYP3A4CYP2C19JAK2 | |
| SCHEMBL17736232 | 0.88 | KDM4E (0.32) | MAPTALDH1A1FGFR4 | |
| SCHEMBL18373834 | 0.87 | MAPT (0.33) | FGFR1FGFR3CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL17728880 | 0.86 | HCAR3 (0.39) | SMN1; SMN2MAPTALDH1A1FGFR4 | |
| SCHEMBL16659558 | 0.86 | ALDH1A1 (0.36) | SMN1; SMN2MAPTALDH1A1FGFR4 | |
| SCHEMBL16659508 | 0.85 | FGFR1 (0.33) | FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL16665233 | 0.84 | FGFR1 (0.48) | FGFR1FGFR3FGFR2FGFR4 | |
| SCHEMBL16659602 | 0.82 | PRMT5 (0.37) | SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |