Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GCK | P35557 | 1/20 | 0.45 |
| ▸ | RNF4 | P78317 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665343 | 0.80 | P2RX3 (0.52) | GCKLMNAL3MBTL1 | |
| SCHEMBL16665332 | 0.75 | GRM5 (0.41) | GRM5HTTGCKLMNASMN1; SMN2 | |
| SCHEMBL16665247 | 0.74 | FGFR4 (0.48) | GRM5GCKSCN5ASCN9A | |
| SCHEMBL31703420 | 0.73 | ALDH1A1 (0.56) | ALDH1A1HTTMITFPOLBMAPK1 | |
| SCHEMBL16665347 | 0.73 | FGFR4 (0.49) | GRM5HTTGCKSCN5ASCN9A | |
| SCHEMBL16665334 | 0.73 | GCK (0.54) | GCK | |
| SCHEMBL31703396 | 0.72 | RNF4 (0.73) | ALDH1A1HTTMITFPOLBMAPK1 | |
| SCHEMBL16665298 | 0.72 | FGFR4 (0.46) | MAPK1 | |
| SCHEMBL16665336 | 0.71 | FGFR4 (0.55) | — | |
| SCHEMBL16665349 | 0.70 | GRM5 (0.47) | GRM5ALDH1A1GCKNOTUMSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |