Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665367 | 0.86 | FGFR4 (0.49) | BRAFMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL16665269 | 0.81 | GCK (0.40) | BRAFMEN1KMT2AKDM4ERAF1 | |
| SCHEMBL16665343 | 0.80 | P2RX3 (0.52) | KDRP2RX3 | |
| SCHEMBL13788617 | 0.73 | BRAF (0.58) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL16665298 | 0.73 | FGFR4 (0.46) | — | |
| SCHEMBL16665300 | 0.71 | FGFR4 (0.46) | BRAFKDM4ELCKFYNPDGFRB | |
| SCHEMBL13953729 | 0.70 | BRAF (0.71) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL16665285 | 0.68 | GRM5 (0.49) | HTT | |
| SCHEMBL4338703 | 0.67 | BRAF (0.82) | BRAFRAF1LCKFYNPDGFRB | |
| SCHEMBL11719516 | 0.67 | MEN1 (0.64) | MEN1KMT2AKDM4ETDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |