Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.49 |
| ▸ | PRKDC | P78527 | 11/20 | 0.49 |
| ▸ | ABL1 | P00519 | 10/20 | 0.49 |
| ▸ | HCK | P08631 | 10/20 | 0.49 |
| ▸ | SRC | P12931 | 10/20 | 0.49 |
| ▸ | KDR | P35968 | 10/20 | 0.49 |
| ▸ | MTOR | P42345 | 10/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 10/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.49 |
| ▸ | BTK | Q06187 | 4/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665815 | 0.88 | SRC (0.49) | EGFRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16665804 | 0.87 | SRC (0.50) | EGFRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16665711 | 0.82 | PIK3CD (0.62) | EGFRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16665783 | 0.80 | EGFR (0.46) | EGFRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16665841 | 0.80 | ATR (0.61) | EGFRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16665809 | 0.77 | RET (0.43) | EGFRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL22243265 | 0.75 | BTK (0.67) | EGFRABL1HCKSRCKDR | |
| SCHEMBL16665849 | 0.75 | PIK3CD (0.53) | EGFRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16655347 | 0.75 | ATR (0.76) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL6430687 | 0.74 | BTK (0.82) | EGFRPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015058084-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-04-23 | — | — | WO | disclosed |