Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 8/20 | 0.43 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.38 |
| ▸ | KDR | P35968 | 8/20 | 0.37 |
| ▸ | SRC | P12931 | 5/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665682 | 0.77 | EGFR (0.51) | EGFRPIK3CDKDRSRCLCK | |
| SCHEMBL16665815 | 0.74 | SRC (0.49) | RETEGFRPIK3CDKDRSRC | |
| SCHEMBL16655772 | 0.73 | ATR (0.59) | RETPIK3CD | |
| SCHEMBL16665783 | 0.73 | EGFR (0.46) | RETEGFRPIK3CDKDRSRC | |
| SCHEMBL16665804 | 0.73 | SRC (0.50) | RETEGFRPIK3CDKDRSRC | |
| SCHEMBL16665711 | 0.71 | PIK3CD (0.62) | EGFRPIK3CDKDRSRCPIK3CA | |
| SCHEMBL23917274 | 0.69 | RET (0.51) | RETEGFRCSNK1A1CSNK1DCSNK1E | |
| SCHEMBL16665776 | 0.68 | BTK (0.40) | RETEGFRCSNK1A1CSNK1DPIK3CD | |
| SCHEMBL24651098 | 0.67 | RET (0.59) | RETEGFRCSNK1A1CSNK1DCSNK1E | |
| SCHEMBL16665841 | 0.67 | ATR (0.61) | EGFRPIK3CDKDRSRCPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015058084-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-04-23 | — | — | WO | disclosed |