Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.68 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.68 |
| ▸ | XDH | P47989 | 1/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | LDHA | P00338 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.53 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.53 |
| ▸ | TRPV2 | Q9Y5S1 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.52 |
| ▸ | BACE1 | P56817 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cordiachromene A SCHEMBL9356402 | 1.00 | PTGS1 (0.68) | PTGS1PTGS2XDHALOX5SLC6A2 | |
| Cordiachromene A SCHEMBL16666288 | 1.00 | PTGS1 (0.68) | PTGS1PTGS2XDHALOX5SLC6A2 | |
| SCHEMBL9360427 | 0.93 | APP (0.63) | PTGS1PTGS2XDHALOX5SLC6A2 | |
| SCHEMBL9360432 | 0.93 | APP (0.63) | PTGS1PTGS2XDHALOX5SLC6A2 | |
| SCHEMBL9356392 | 0.93 | APP (0.63) | PTGS1PTGS2XDHALOX5SLC6A2 | |
| SCHEMBL9356386 | 0.93 | APP (0.63) | PTGS1PTGS2XDHALOX5SLC6A2 | |
| SCHEMBL10536271 | 0.91 | PTGS1 (0.60) | PTGS1PTGS2XDHALOX5SLC6A2 | |
| Elaeagin SCHEMBL29754176 | 0.87 | PTGS1 (0.61) | PTGS1PTGS2XDHALOX5SLC6A2 | |
| SCHEMBL14283918 | 0.82 | ALOX5 (0.62) | PTGS1ALOX5SLC6A2TRPA1LDHA | |
| Daedalin A SCHEMBL29983386 | 0.81 | PTGS1 (1.00) | PTGS1PTGS2XDHALOX5BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2865677-B1 | Synthesis of chromane compounds and their derivatives by a copper-catalyzed conjugate addition reaction | DSM IP ASSETS BV (NL) | 2016-11-23 | — | — | EP | disclosed |
| WO-2015059129-A1 | SYNTHESIS OF CHROMANE COMPOUNDS AND THEIR DERIVATIVES BY A COPPER-CATALYZED CONJUGATE ADDITION REACTION | DSM IP ASSETS B.V. (NL) | 2015-04-30 | — | — | WO | disclosed |
| EP-2865677-A1 | Synthesis of chromane compounds and their derivatives by a copper-catalyzed conjugate addition reaction | DSM IP Assets B.V. (NL) | 2015-04-29 | — | — | EP | disclosed |