Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | TTPA | P49638 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16666279 | 1.00 | PSEN1 (0.47) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL16671460 | 0.92 | MEN1 (0.45) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL16666298 | 0.92 | MEN1 (0.45) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL16666299 | 0.92 | MEN1 (0.45) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL16666352 | 0.82 | PSEN1 (0.40) | PSEN1PTPN1 | |
| SCHEMBL16666422 | 0.77 | AKT1 (0.52) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL16666419 | 0.77 | AKT1 (0.52) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL16666423 | 0.77 | AKT1 (0.52) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL16667485 | 0.74 | DNTT (0.41) | PSEN1KMT2ALMNA | |
| SCHEMBL16667486 | 0.74 | DNTT (0.41) | PSEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2865677-A1 | Synthesis of chromane compounds and their derivatives by a copper-catalyzed conjugate addition reaction | DSM IP Assets B.V. (NL) | 2015-04-29 | — | — | EP | disclosed |