Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNTT | P04053 | 3/20 | 0.41 |
| ▸ | POLA1 | P09884 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16667486 | 1.00 | DNTT (0.41) | DNTTPOLA1POLBPSEN1RAB9A | |
| SCHEMBL16666352 | 0.91 | PSEN1 (0.40) | DNTTPOLA1POLBPSEN1 | |
| SCHEMBL16666298 | 0.83 | MEN1 (0.45) | PSEN1LMNAKMT2A | |
| SCHEMBL16666299 | 0.83 | MEN1 (0.45) | PSEN1LMNAKMT2A | |
| SCHEMBL16671460 | 0.83 | MEN1 (0.45) | PSEN1LMNAKMT2A | |
| SCHEMBL16666279 | 0.74 | PSEN1 (0.47) | PSEN1LMNAKMT2A | |
| SCHEMBL16666281 | 0.74 | PSEN1 (0.47) | PSEN1LMNAKMT2A | |
| SCHEMBL16666394 | 0.73 | PTPN1 (0.39) | PSEN1KMT2A | |
| SCHEMBL16666396 | 0.73 | PTPN1 (0.39) | PSEN1KMT2A | |
| SCHEMBL9690164 | 0.64 | POLA1 (0.44) | DNTTPOLA1POLBRAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2865677-B1 | Synthesis of chromane compounds and their derivatives by a copper-catalyzed conjugate addition reaction | DSM IP ASSETS BV (NL) | 2016-11-23 | — | — | EP | disclosed |
| EP-2865677-B1 | Synthesis of chromane compounds and their derivatives by a copper-catalyzed conjugate addition reaction | DSM IP ASSETS BV (NL) | 2016-11-23 | — | — | EP | disclosed |
| EP-2865677-A1 | Synthesis of chromane compounds and their derivatives by a copper-catalyzed conjugate addition reaction | DSM IP Assets B.V. (NL) | 2015-04-29 | — | — | EP | disclosed |
| EP-2865677-A1 | Synthesis of chromane compounds and their derivatives by a copper-catalyzed conjugate addition reaction | DSM IP Assets B.V. (NL) | 2015-04-29 | — | — | EP | disclosed |