Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.33 |
| ▸ | HTR2B | P41595 | 8/20 | 0.33 |
| ▸ | HTR2A | P28223 | 6/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.33 |
| ▸ | PRKCG | P05129 | 2/20 | 0.33 |
| ▸ | PRKCB | P05771 | 2/20 | 0.33 |
| ▸ | PRKCA | P17252 | 2/20 | 0.33 |
| ▸ | PRKACA | P17612 | 2/20 | 0.33 |
| ▸ | PRKACG | P22612 | 2/20 | 0.33 |
| ▸ | PRKACB | P22694 | 2/20 | 0.33 |
| ▸ | PRKCH | P24723 | 2/20 | 0.33 |
| ▸ | PRKCI | P41743 | 2/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12536836 | 0.70 | PSEN1 (0.46) | SMN1; SMN2MEN1CYP3A4CYP2C19KMT2A | |
| SCHEMBL1667741 | 0.70 | SLC18A3 (0.33) | HTR2CHTR2BHTR2ATAAR1 | |
| SCHEMBL5511188 | 0.70 | RAB9A (0.47) | SMN1; SMN2MEN1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4710814 | 0.70 | ALDH1A1 (0.41) | HTR2CHTR2BHTR2ASMYD3CYP2D6 | |
| SCHEMBL29456646 | 0.69 | SMYD3 (0.40) | HTR2CHTR2BHTR2ASMYD3SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28210755 | 0.69 | KMT2A (0.41) | HTR2CHTR2BHTR2ASMYD3SMN1; SMN2 | |
| SCHEMBL28623338 | 0.68 | HTR2C (0.43) | HTR2CHTR2BHTR2ASMN1; SMN2MEN1 | |
| SCHEMBL7017637 | 0.66 | HTR2C (0.38) | HTR2CHTR2BHTR2APRKD3PRKCG | |
| SCHEMBL12536865 | 0.65 | MAPT (0.45) | CYP2D6ALDH1A1LMNA | |
| SCHEMBL28211336 | 0.64 | ALDH1A1 (0.46) | PRKD3PRKCGPRKCBPRKCAPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | claimed |
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |