Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 6/20 | 0.46 |
| ▸ | GNAO1 | P09471 | 6/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GUSB | P08236 | 2/20 | 0.37 |
| ▸ | EBP | Q15125 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15590865 | 0.98 | GNAI3 (0.47) | GNAI3GNAO1GNAI1ALDH1A1CYP1A2 | |
| SCHEMBL15590864 | 0.98 | GNAI3 (0.47) | GNAI3GNAO1GNAI1ALDH1A1CYP1A2 | |
| SCHEMBL16487999 | 0.98 | GNAI3 (0.47) | GNAI3GNAO1GNAI1ALDH1A1CYP1A2 | |
| SCHEMBL15590866 | 0.98 | GNAI3 (0.47) | GNAI3GNAO1GNAI1ALDH1A1CYP1A2 | |
| SCHEMBL19792133 | 0.98 | GNAI3 (0.47) | GNAI3GNAO1GNAI1ALDH1A1CYP1A2 | |
| SCHEMBL16487995 | 0.98 | GNAI3 (0.47) | GNAI3GNAO1GNAI1ALDH1A1CYP1A2 | |
| SCHEMBL15590758 | 0.91 | GNAI3 (0.37) | GNAI3GNAO1GNAI1KDM4ELMNA | |
| SCHEMBL15590794 | 0.89 | HRH3 (0.37) | GNAI3GNAO1GNAI1KCNH2 | |
| SCHEMBL15590867 | 0.89 | HRH3 (0.37) | GNAI3GNAO1GNAI1KCNH2 | |
| SCHEMBL15689958 | 0.89 | HRH3 (0.37) | GNAI3GNAO1GNAI1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015061097-A1 | LUBRICIOUS, ANTI-ADHESIVE COATINGS | BASF SE (DE) | 2015-04-30 | — | — | WO | disclosed |