Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16670529 | 0.81 | CHRNB2 (0.34) | ALDH1A1ROCK2ROCK1CDC42BPBHRH3 | |
| SCHEMBL27978355 | 0.74 | HTR2A (0.38) | HTR2AHTR2CHTR2BP2RX7KARS1 | |
| SCHEMBL15737883 | 0.69 | CYP3A4 (0.43) | ALDH1A1HTR2CHRH3 | |
| SCHEMBL4012037 | 0.69 | CHEK1 (0.36) | ALDH1A1HTR2AHTR2CHTR2BCHEK1 | |
| SCHEMBL4020584 | 0.67 | HRH3 (0.36) | ALDH1A1ROCK2ROCK1CDC42BPBHRH3 | |
| SCHEMBL28412863 | 0.66 | GPR119 (0.45) | — | |
| SCHEMBL29757596 | 0.66 | GPR119 (0.45) | — | |
| SCHEMBL15587834 | 0.65 | CHEK1 (0.51) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL3460332 | 0.65 | CHEK1 (0.51) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL29889443 | 0.64 | CHEK1 (0.41) | CHEK1CCNA2CDK2CCNA1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160281165-A1 | METHODS FOR DIAGNOSING, SCREENING, IDENTIFYING, MONITORING, AND TREATING ADVERSE LOCAL TISSUE REACTIONS, WHICH LEAD TO FAILURE OF ORTHOPEDIC IMPLANTS | NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY | 2016-09-29 | — | — | US | disclosed |
| WO-2015061534-A1 | METHODS FOR DIAGNOSING, SCREENING, IDENTIFYING, MONITORING, AND TREATING ADVERSE LOCAL TISSUE REACTIONS IN ORTHOPEDIC IMPLANTS | NEW YORK SOCIETY FOR THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY (US) | 2015-04-30 | — | — | WO | disclosed |