SCHEMBL16670591

SCHEMBL16670591

CCNc1c(Cl)n[nH]c1-c1cccnc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.40
CYP2C19 P33261 3/20 0.40
TDP1 Q9NUW8 1/20 0.40
ALK Q9UM73 1/20 0.39
ADORA2A P29274 1/20 0.39
ADORA1 P30542 1/20 0.39
MKNK1 Q9BUB5 1/20 0.39
MKNK2 Q9HBH9 1/20 0.39
CYP2A6 P11509 5/20 0.38
CYP3A4 P08684 3/20 0.38
ALDH1A1 P00352 3/20 0.38
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
BTK Q06187 1/20 0.37
CYP2B6 P20813 3/20 0.37
CYP2D6 P10635 2/20 0.37
CYP2C9 P11712 2/20 0.37
CYP2E1 P05181 2/20 0.36
DYRK1A Q13627 1/20 0.36
CLK4 Q9HAZ1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16670756 0.84 CYP2A6 (0.42) CYP1A2CYP2C19ALKCYP2A6CYP3A4
SCHEMBL2723781 0.81 ALK (0.39) CYP1A2CYP2C19ALKCYP2A6CYP3A4
SCHEMBL16671156 0.75 PKM (0.42) CYP1A2ADORA2AADORA1DYRK1APKM
SCHEMBL28021139 0.68 IDO1 (0.54) CYP1A2ALKCYP2A6CYP3A4ALDH1A1
SCHEMBL16671557 0.67 ALK (0.40) CYP1A2CYP2C19ALKMKNK1MKNK2
SCHEMBL290281 0.67 NPC1 (0.44) CYP1A2CYP2C19ADORA2AADORA1MKNK1
SCHEMBL20729480 0.66 CYP2A6 (0.54) CYP1A2CYP2C19ADORA2AADORA1MKNK1
Hydrochloric Acid SCHEMBL30994427 0.66 NPC1 (0.43) CYP1A2CYP2C19ADORA2AADORA1MKNK1
Hydrochloric Acid SCHEMBL29282726 0.66 NPC1 (0.43) CYP1A2CYP2C19ADORA2AADORA1MKNK1
Hydrochloric Acid SCHEMBL290178 0.66 NPC1 (0.43) CYP1A2CYP2C19ADORA2AADORA1MKNK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3071036-A1 PESTICIDAL COMPOSITIONS AND RELATED METHODS Dow AgroSciences LLC (US) 2016-09-28 EP disclosed
WO-2015061165-A1 PESTICIDAL COMPOSITIONS AND RELATED METHODS DOW AGROSCIENCES LLC (US) 2015-04-30 WO disclosed