Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 3/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15660759 | 0.93 | IDO1 (0.55) | IDO1LRRK2PIM1MAP2K4AXL | |
| SCHEMBL3464003 | 0.81 | MAP2K4 (0.55) | IDO1LRRK2PIM1MAP2K4AXL | |
| SCHEMBL16200084 | 0.78 | CYP2A6 (0.41) | IDO1LRRK2PIM1CYP2A6ALDH1A1 | |
| SCHEMBL13739801 | 0.76 | ALDH1A1 (0.60) | IDO1ALDH1A1CYP1A2CYP3A4TTK | |
| SCHEMBL25288258 | 0.72 | IDO1 (0.58) | IDO1LRRK2PIM1MAP2K4AXL | |
| SCHEMBL17279845 | 0.71 | ALDH1A1 (0.50) | IDO1MAP2K4ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL16670756 | 0.71 | CYP2A6 (0.42) | IDO1LRRK2PIM1MAP2K4CYP2A6 | |
| SCHEMBL22801811 | 0.71 | FYN (0.43) | IDO1LRRK2PIM1CYP2A6ALDH1A1 | |
| SCHEMBL22819372 | 0.71 | IDO1 (0.60) | IDO1LRRK2PIM1MAP2K4AXL | |
| SCHEMBL9394628 | 0.70 | IDO1 (0.56) | IDO1LRRK2PIM1MAP2K4AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104860927-A | 1H-3,5-bis(3-pyridinyl)-4-chloropyrazole compound, and preparation method and application thereof | UNIV NINGBO | 2015-08-26 | — | — | CN | claimed |
| CN-104860927-A | 1H-3,5-bis(3-pyridinyl)-4-chloropyrazole compound, and preparation method and application thereof | UNIV NINGBO | 2015-08-26 | — | — | CN | disclosed |
| CN-104860927-A | 1H-3,5-bis(3-pyridinyl)-4-chloropyrazole compound, and preparation method and application thereof | UNIV NINGBO | 2015-08-26 | — | — | CN | disclosed |
| CN-104860927-A | 1H-3,5-bis(3-pyridinyl)-4-chloropyrazole compound, and preparation method and application thereof | UNIV NINGBO | 2015-08-26 | — | — | CN | disclosed |