SCHEMBL16670730

SCHEMBL16670730

CC(=O)c1cc(CN)ccc1Cl

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CSNK2A1 P68400 7/20 0.45
CYP4F2 P78329 1/20 0.44
CYP4A11 Q02928 1/20 0.44
KLKB1 P03952 2/20 0.43
CSNK2A2 P19784 1/20 0.41
CSNK2B P67870 1/20 0.41
CSNK2A3 Q8NEV1 1/20 0.41
ALDH1A1 P00352 1/20 0.41
LOXL2 Q9Y4K0 2/20 0.40
MAOA P21397 2/20 0.40
MAOB P27338 2/20 0.40
KDM4E B2RXH2 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
SMYD3 Q9H7B4 1/20 0.39
USP28 Q96RU2 1/20 0.39
PNMT P11086 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1671897 0.83 ALDH1A1 (0.57) CSNK2A1CYP4F2CYP4A11KLKB1ALDH1A1
SCHEMBL22627397 0.83 ALDH1A1 (0.47) CSNK2A1CYP4F2CYP4A11KLKB1CSNK2A2
Hydrochloric Acid SCHEMBL1671401 0.81 ALDH1A1 (0.55) CSNK2A1CYP4F2CYP4A11KLKB1ALDH1A1
SCHEMBL31343271 0.81 LOXL2 (0.54) CYP4F2CYP4A11ALDH1A1LOXL2KDM4E
SCHEMBL14817015 0.81 LOXL2 (0.54) CYP4F2CYP4A11ALDH1A1LOXL2KDM4E
Hydrochloric Acid SCHEMBL30933600 0.80 LOXL2 (0.53) CSNK2A1CYP4F2CYP4A11ALDH1A1LOXL2
Hydrochloric Acid SCHEMBL9931554 0.80 LOXL2 (0.53) CSNK2A1CYP4F2CYP4A11ALDH1A1LOXL2
SCHEMBL11207193 0.79 ALDH1A1 (0.52) KLKB1ALDH1A1LOXL2MAOBKDM4E
SCHEMBL21632307 0.79 PLG (0.49) KLKB1MAOAMAOBKDM4ESMN1; SMN2
SCHEMBL18006675 0.79 CYP4F2 (0.45) CYP4F2CYP4A11ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015059618-A1 SUBSTITUTED PYRIMIDINE COMPOUNDS AS mPGES-1 INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2015-04-30 WO disclosed
WO-2015059618-A1 SUBSTITUTED PYRIMIDINE COMPOUNDS AS mPGES-1 INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2015-04-30 WO disclosed