Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 2/20 | 0.59 |
| ▸ | PRKCA | P17252 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.59 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.59 |
| ▸ | CDK4 | P11802 | 2/20 | 0.57 |
| ▸ | CDK2 | P24941 | 2/20 | 0.57 |
| ▸ | PLK1 | P53350 | 3/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | BCR | P11274 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | IKBKB | O14920 | 2/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667086 | 0.89 | PLK1 (0.68) | SYKABL1PRKCASMG1CDK4 | |
| SCHEMBL12275241 | 0.89 | PLK1 (0.61) | SYKABL1EGFRSMG1CDK4 | |
| SCHEMBL12274499 | 0.89 | PLK1 (0.73) | SYKABL1PRKCAPRKCDSMG1 | |
| SCHEMBL1667452 | 0.88 | SYK (0.58) | SYKABL1PRKCASMG1CDK4 | |
| SCHEMBL6508664 | 0.88 | CAMK2D (0.69) | SYKABL1PRKCAPRKCDSMG1 | |
| SCHEMBL12275151 | 0.86 | BRD4 (0.54) | SYKABL1SMG1CDK4CDK2 | |
| SCHEMBL12274527 | 0.86 | BRD4 (0.54) | SYKABL1PRKCASMG1CDK4 | |
| SCHEMBL12274360 | 0.86 | SYK (0.62) | SYKABL1PRKCASMG1CDK4 | |
| SCHEMBL1667472 | 0.86 | MEN1 (0.75) | CDK4PLK1BRD4DYRK1AIKBKB | |
| SCHEMBL12274124 | 0.85 | SYK (0.62) | SYKABL1PRKCAEGFRPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102791697-A | Amino-pyrimidine compounds as inhibitors of TBKL and/or IKK epsilon | MYREXIS INC | 2012-11-21 | — | — | CN | claimed |
| US-20120238540-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1 | MYREXIS, INC. (US) | 2012-09-20 | — | — | US | claimed |
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | claimed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | claimed |
| US-20150352108-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON | ALZHEIMER'S INSTITUTE OF AMERICA (US) | 2015-12-10 | — | — | US | disclosed |
| CN-102791697-A | Amino-pyrimidine compounds as inhibitors of TBKL and/or IKK epsilon | MYREXIS INC | 2012-11-21 | — | — | CN | disclosed |
| US-20120238540-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1 | MYREXIS, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |
| US-7304071-B2 | Protein kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-04 | — | — | US | disclosed |
| CN-1863780-A | Protein kinase inhibitor and application thereof | VERTEX PHARMA (US) | 2006-11-15 | — | — | CN | disclosed |
| EP-1546117-A2 | PROTEIN KINASE INHIBITORS AND USES THEREOF | Vertex Pharmaceuticals Incorporated (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040106615-A1 | Protein kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-06-03 | — | — | US | disclosed |
| WO-2004016597-A2 | PROTEIN KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106615-A1 | Protein kinase inhibitors and uses thereof | JAK1, RAF1, PRKCQ | SYK 501/4885ADORA2B 4003/4885ADORA1 3891/4885 |
| US-20150352108-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON | TBK1, NFKBIA, CHUK | SYK 122/4885ADORA2B 2369/4885ADORA1 1461/4885 |
| US-20120238540-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1 | TBK1, NFKBIA, IKBKB | SYK 112/4885ADORA2B 2227/4885ADORA1 1285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.