Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 4/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29458465 | 0.90 | F10 (0.46) | ROCK2KMT2AMEN1LMNAALOX15 | |
| SCHEMBL22644319 | 0.90 | F10 (0.46) | ROCK2KMT2AMEN1LMNAALOX15 | |
| Hydrochloric Acid SCHEMBL22632743 | 0.89 | F10 (0.45) | ROCK2KMT2AMEN1LMNAALOX15 | |
| Hydrochloric Acid SCHEMBL16671518 | 0.89 | F10 (0.45) | ROCK2KMT2AMEN1LMNAALOX15 | |
| SCHEMBL21670326 | 0.84 | MGLL (0.52) | ROCK2KMT2AMEN1LMNAHPGD | |
| SCHEMBL22644321 | 0.84 | MALT1 (0.58) | KMT2AMEN1LMNAHPGDALOX15 | |
| SCHEMBL18045233 | 0.84 | F10 (0.40) | ROCK2KMT2AMEN1LMNAHPGD | |
| SCHEMBL18045234 | 0.84 | F10 (0.40) | ROCK2KMT2AMEN1LMNAHPGD | |
| SCHEMBL29458485 | 0.84 | MALT1 (0.58) | KMT2AMEN1LMNAHPGDALOX15 | |
| Hydrochloric Acid SCHEMBL16671308 | 0.83 | F10 (0.39) | ROCK2KMT2AMEN1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060547-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | Janssen Sciences Ireland UC (IE) | 2016-08-31 | — | — | EP | disclosed |
| WO-2015059212-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN R&D IRELAND (IE) | 2015-04-30 | — | — | WO | disclosed |