Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | VEGFA | P15692 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19640914 | 0.89 | L3MBTL1 (0.47) | L3MBTL1VEGFAEGLN1CYP2C19PTGDR2 | |
| SCHEMBL1933800 | 0.87 | L3MBTL1 (0.39) | L3MBTL1VEGFAEGLN1POLBALDH3A1 | |
| SCHEMBL27873416 | 0.84 | L3MBTL1 (0.46) | L3MBTL1VEGFAEGLN1CYP2C19PTGDR2 | |
| SCHEMBL4346386 | 0.84 | ALDH1A1 (0.40) | L3MBTL1VEGFAEGLN1POLBHTT | |
| SCHEMBL2318675 | 0.83 | L3MBTL1 (0.47) | L3MBTL1VEGFAEGLN1CYP2C19PTGDR2 | |
| SCHEMBL4357413 | 0.77 | L3MBTL1 (0.50) | L3MBTL1CYP2C19POLBALDH3A1HTT | |
| SCHEMBL9990912 | 0.77 | L3MBTL1 (0.36) | L3MBTL1VEGFAEGLN1HTTALDH1A1 | |
| SCHEMBL9990330 | 0.76 | L3MBTL1 (0.45) | L3MBTL1VEGFAEGLN1POLBALDH3A1 | |
| SCHEMBL1933942 | 0.76 | L3MBTL1 (0.51) | L3MBTL1VEGFAEGLN1CYP2C19PTGDR2 | |
| SCHEMBL14794936 | 0.76 | L3MBTL1 (0.39) | L3MBTL1VEGFAEGLN1POLBALDH3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060234-A1 | JAK1 SELECTIVE INHIBITOR AND USES THEREOF | AbbVie Inc. (US) | 2016-08-31 | — | — | EP | disclosed |
| WO-2015061665-A1 | JAK1 SELECTIVE INHIBITOR AND USES THEREOF | ABBVIE INC. (US) | 2015-04-30 | — | — | WO | disclosed |