SCHEMBL16670980

SCHEMBL16670980

CC(C)(C)C(=O)NCc1ccc(Cl)c(C=O)c1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PTGES O14684 9/20 0.49
HDAC6 Q9UBN7 1/20 0.48
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA7 P43166 1/20 0.47
CA14 Q9ULX7 1/20 0.47
F2R P25116 4/20 0.47
TSHR P16473 2/20 0.47
CNR2 P34972 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
HPGD P15428 1/20 0.41
SMO Q99835 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1750145 0.84 TSHR (0.50) HDAC6TSHRSMN1; SMN2HPGD
SCHEMBL1751039 0.82 TSHR (0.69) TSHRSMN1; SMN2HPGD
SCHEMBL29952190 0.82 TSHR (0.54) HDAC6CA1CA2TSHRSMN1; SMN2
SCHEMBL1750878 0.81 TSHR (0.48) TSHRSMN1; SMN2HPGD
SCHEMBL15033692 0.81 PTGES (0.52) PTGESHDAC6CA1CA2CA7
SCHEMBL16181920 0.80 PTGES (0.49) PTGESHDAC6CA1CA2CA7
SCHEMBL16671183 0.80 ERCC1 (0.56) PTGESTSHR
SCHEMBL671821 0.79 CA1 (0.52) PTGESHDAC6CA1CA2CA7
SCHEMBL16671197 0.79 PTGES (0.51) PTGESHDAC6CA1CA2CA7
SCHEMBL17199049 0.78 PTGES (0.59) PTGESHDAC6CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023127883-A1 INDAZOLE COMPOUND AND PHARMACEUTICAL 日本新薬株式会社 2023-07-06 WO disclosed
EP-3133068-B1 AMIDE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREFOR AND MEDICINAL APPLICATION THEREOF Shanghai hengrui pharmaceutical co ltd (CN) 2020-11-25 EP disclosed
WO-2015059618-A1 SUBSTITUTED PYRIMIDINE COMPOUNDS AS mPGES-1 INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2015-04-30 WO disclosed
WO-2015059618-A1 SUBSTITUTED PYRIMIDINE COMPOUNDS AS mPGES-1 INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2015-04-30 WO disclosed