Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 3/20 | 0.41 |
| ▸ | ERCC4 | Q92889 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1750145 | 0.85 | TSHR (0.50) | TSHRSMN1; SMN2HPGDALDH1A1LMNA | |
| SCHEMBL1751039 | 0.84 | TSHR (0.69) | TSHRSMN1; SMN2HPGDALDH1A1LMNA | |
| SCHEMBL30259914 | 0.83 | TSHR (0.68) | TSHRSMN1; SMN2TRPV1HPGDALDH1A1 | |
| SCHEMBL6361222 | 0.83 | TSHR (0.68) | TSHRSMN1; SMN2TRPV1HPGDALDH1A1 | |
| SCHEMBL1751145 | 0.82 | TSHR (0.41) | TSHRSMN1; SMN2TRPV1HPGDP2RX7 | |
| SCHEMBL16670980 | 0.81 | PTGES (0.49) | TSHRSMN1; SMN2HPGD | |
| SCHEMBL16671183 | 0.81 | ERCC1 (0.56) | TSHRERCC1ERCC4 | |
| SCHEMBL1751352 | 0.80 | ERCC1 (0.51) | SMN1; SMN2HPGDALDH1A1P2RX7ERCC1 | |
| SCHEMBL1750408 | 0.79 | TSHR (0.50) | TSHRSMN1; SMN2TRPV1HPGDALDH1A1 | |
| SCHEMBL29952190 | 0.78 | TSHR (0.54) | TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968720-B2 | Secondary amines as renin inhibitors | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-06-28 | — | — | US | disclosed |
| US-20090176823-A1 | Secondary Amines as Renin Inhibitors | ACTELION PHARMACEUTICALS LTD. (CH) | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176823-A1 | Secondary Amines as Renin Inhibitors | REN, ACE, AGTR1 | TSHR 1994/4885SMN1; SMN2 4441/4885TRPV1 2353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.