Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.54 |
| ▸ | BCR | P11274 | 8/20 | 0.54 |
| ▸ | PRKCA | P17252 | 5/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | PRKCB | P05771 | 1/20 | 0.48 |
| ▸ | PRKCH | P24723 | 1/20 | 0.48 |
| ▸ | PRKCI | P41743 | 1/20 | 0.48 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12274532 | 0.93 | JAK2 (0.58) | ABL1BCRPRKCAPDGFRBPDGFRA | |
| SCHEMBL1667130 | 0.91 | MEN1 (0.53) | ABL1BCRPRKCAJAK2PIK3CG | |
| SCHEMBL12274769 | 0.90 | MEN1 (0.49) | ABL1BCRPRKCAPDGFRBPDGFRA | |
| SCHEMBL12522328 | 0.88 | AAK1 (0.57) | ABL1BCRPRKCAPDGFRBPDGFRA | |
| SCHEMBL12274689 | 0.87 | MEN1 (0.56) | ABL1PRKCAEGFRJAK2FLT3 | |
| SCHEMBL12274596 | 0.87 | ABL1 (0.49) | ABL1BCRPRKCAPDGFRBPDGFRA | |
| SCHEMBL12274595 | 0.85 | GSK3B (0.48) | ABL1BCRPRKCAPDGFRBPDGFRA | |
| SCHEMBL12274908 | 0.85 | ABL1 (0.48) | ABL1BCRPRKCAPDGFRBPDGFRA | |
| SCHEMBL12274601 | 0.85 | PRKCA (0.49) | ABL1BCRPRKCAPDGFRBPDGFRA | |
| SCHEMBL12274536 | 0.84 | CDK5 (0.67) | ABL1BCREGFRJAK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150352108-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON | ALZHEIMER'S INSTITUTE OF AMERICA (US) | 2015-12-10 | — | — | US | disclosed |
| US-20120238540-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1 | MYREXIS, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150352108-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON | TBK1, NFKBIA, CHUK | ABL1 2170/4885BCR 3807/4885PRKCA 49/4885 |
| US-20120238540-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1 | TBK1, NFKBIA, IKBKB | ABL1 538/4885BCR 2523/4885PRKCA 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.