Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 4/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.43 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12027635 | 1.00 | ADRA2C (0.50) | ADRA2CPDGFRBFGFR1KDRHTR6 | |
| SCHEMBL3440424 | 0.90 | ADRA2C (0.57) | ADRA2CPDGFRBFGFR1KDRMAPT | |
| SCHEMBL29833219 | 0.86 | PDGFRB (0.41) | ADRA2CPDGFRBFGFR1KDRHTR6 | |
| SCHEMBL14980549 | 0.84 | NOTUM (0.57) | HTR6HTR2BMCHR1MAPTALDH1A1 | |
| SCHEMBL4186891 | 0.83 | NPY5R (0.48) | PDGFRBFGFR1KDRHTR6HTR2B | |
| SCHEMBL188111 | 0.82 | MCHR1 (0.48) | ADRA2CMAP4K4MCHR1MAPTKDM4E | |
| SCHEMBL188110 | 0.82 | MCHR1 (0.48) | ADRA2CMAP4K4MCHR1MAPTKDM4E | |
| SCHEMBL188535 | 0.82 | MCHR1 (0.48) | ADRA2CMAP4K4MCHR1MAPTKDM4E | |
| SCHEMBL13174962 | 0.82 | MCHR1 (0.56) | HTR6MCHR1KCNH2NOTUMHTR1D | |
| SCHEMBL16719407 | 0.82 | MCHR1 (0.56) | HTR6MCHR1KCNH2NOTUMHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188251-B1 | ARYLSULFONAMIDES WITH ANALGESIC ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2015-04-29 | — | — | EP | disclosed |