Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | BPTF | Q12830 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15928755 | 1.00 | ADRA2C (0.54) | ADRA2CALDH1A1HTTPDK2MEN1 | |
| SCHEMBL14578437 | 0.89 | ADRA2C (0.62) | ADRA2CALDH1A1HTTMEN1KMT2A | |
| SCHEMBL21014722 | 0.85 | ADRA2C (0.56) | ADRA2CALDH1A1HTTMEN1KMT2A | |
| SCHEMBL11934695 | 0.82 | ADRA2C (0.53) | ADRA2CALDH1A1HTTMEN1KMT2A | |
| SCHEMBL10472128 | 0.81 | NOTUM (0.61) | ALDH1A1HTTMAPTNOTUML3MBTL1 | |
| SCHEMBL12862539 | 0.81 | OPRM1 (0.50) | ALDH1A1PDK2MEN1KMT2ANOTUM | |
| SCHEMBL8276477 | 0.81 | BPTF (0.47) | PDK2MEN1KMT2AGAAUSP2 | |
| SCHEMBL16330372 | 0.80 | MAPT (0.50) | ADRA2CALDH1A1HTTPDK2MEN1 | |
| SCHEMBL15650643 | 0.80 | MAPT (0.50) | ADRA2CALDH1A1HTTPDK2MEN1 | |
| SCHEMBL12449705 | 0.80 | NOTUM (0.55) | ALDH1A1HTTPDK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188251-B1 | ARYLSULFONAMIDES WITH ANALGESIC ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2015-04-29 | — | — | EP | disclosed |