SCHEMBL16675978

SCHEMBL16675978

CC(C)(O)c1ccc2cc(-c3n[nH]c4ccsc34)[nH]c2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITK Q08881 20/20 1.00
LCK P06239 6/20 1.00
TXK P42681 6/20 1.00
SYK P43405 6/20 1.00
PLK4 O00444 1/20 0.36
CHEK1 O14757 1/20 0.36
AURKA O14965 1/20 0.36
CCNB2 O95067 1/20 0.36
ABL1 P00519 1/20 0.36
CDK1 P06493 1/20 0.36
PDGFRB P09619 1/20 0.36
CDK4 P11802 1/20 0.36
SRC P12931 1/20 0.36
CCNB1 P14635 1/20 0.36
CCNA2 P20248 1/20 0.36
CCND1 P24385 1/20 0.36
CDK2 P24941 1/20 0.36
WEE1 P30291 1/20 0.36
TTK P33981 1/20 0.36
KDR P35968 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1622450 0.89 ITK (0.82) ITKLCKTXKSYK
SCHEMBL1622213 0.87 ITK (1.00) ITKLCKTXKSYKPLK4
SCHEMBL1623389 0.84 ITK (0.72) ITKLCKTXKSYK
SCHEMBL12747703 0.84 ITK (0.77) ITKLCKTXKSYK
SCHEMBL1622393 0.81 ITK (0.67) ITKLCKTXKSYK
SCHEMBL1622709 0.80 ITK (0.72) ITKLCKTXKSYKCHEK1
SCHEMBL1621994 0.80 ITK (0.72) ITKLCKTXKSYKCHEK1
SCHEMBL1622893 0.80 ITK (0.72) ITKLCKTXKSYKCHEK1
SCHEMBL1622620 0.79 ITK (0.65) ITKLCKTXKSYK
SCHEMBL1620633 0.79 ITK (0.65) ITKLCKTXKSYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230340412-A1 Expansion Of Peripheral Blood Lymphocytes (PBLS) From Peripheral Blood IOVANCE BIOTHERAPEUTICS INC (US) 2023-10-26 US disclosed
US-20230340412-A1 Expansion Of Peripheral Blood Lymphocytes (PBLS) From Peripheral Blood IOVANCE BIOTHERAPEUTICS INC (US) 2023-10-26 US disclosed
US-20230165898-A1 EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES FROM LIQUID TUMORS AND THERAPEUTIC USES THEROF IOVANCE BIOTHERAPEUTICS, INC. 2023-06-01 US disclosed
US-20230165898-A1 EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES FROM LIQUID TUMORS AND THERAPEUTIC USES THEROF IOVANCE BIOTHERAPEUTICS, INC. 2023-06-01 US disclosed
US-20230100137-A1 METHODS OF TREATING AND PREVENTING ALLOANTIBODY DRIVEN CHRONIC GRAFT VERSUS HOST DISEASE PHARMACYCLICS LLC (US) 2023-03-30 US disclosed
EP-4115886-A1 METHODS OF TREATING AND PREVENTING GRAFT VERSUS HOST DISEASE Pharmacyclics LLC (US) 2023-01-11 EP disclosed
US-20220133795-A1 Expansion of Tumor Infiltrating Lymphocytes From Liquid Tumors and Therapeutic Uses Thereof IOVANCE BIOTHERAPEUTICS, INC. 2022-05-05 US disclosed
US-20220118011-A1 PROCESSES FOR PRODUCTION OF TUMOR INFILTRATING LYMPHOCYTES AND USES OF SAME IN IMMUNOTHERAPY IOVANCE BIOTHERAPEUTICS, INC. 2022-04-21 US disclosed
US-20210177854-A1 METHODS OF TREATING AND PREVENTING ALLOANTIBODY DRIVEN CHRONIC GRAFT VERSUS HOST DISEASE PHARMACYCLICS LLC 2021-06-17 US disclosed
US-20210121463-A1 METHODS OF TREATING AND PREVENTING GRAFT VERSUS HOST DISEASE PHARMACYCLICS LLC (US) 2021-04-29 US disclosed
WO-2015084892-A1 METHODS FOR TREATING B CELL PROLIFERATIVE DISORDERS CORNELL UNIVERSITY (US) 2015-06-11 WO disclosed
WO-2015073833-A1 METHODS FOR DELAYING OR PREVENTING THE ONSET OF TYPE 1 DIABETES PHARMACYCLICS, INC. (US) 2015-05-21 WO disclosed
US-20150141438-A1 METHODS FOR DELAYING OR PREVENTING THE ONSET OF TYPE 1 DIABETES VANDERBILT UNIVERSITY 2015-05-21 US disclosed
US-20150141438-A1 METHODS FOR DELAYING OR PREVENTING THE ONSET OF TYPE 1 DIABETES VANDERBILT UNIVERSITY 2015-05-21 US disclosed
US-20150118222-A1 TREATMENT USING BRUTON'S TYROSINE KINASE INHIBITORS AND IMMUNOTHERAPY PHARMACYCLICS LLC 2015-04-30 US disclosed
US-20150118222-A1 TREATMENT USING BRUTON'S TYROSINE KINASE INHIBITORS AND IMMUNOTHERAPY PHARMACYCLICS LLC 2015-04-30 US disclosed
WO-2015061751-A1 METHODS OF TREATING AND PREVENTING GRAFT VERSUS HOST DISEASE PHARMACYCLICS, INC. (US) 2015-04-30 WO disclosed
WO-2015061752-A1 TREATMENT USING BRUTON'S TYROSINE KINASE INHIBITORS AND IMMUNOTHERAPY PHARMACYCLICS, INC. (US) 2015-04-30 WO disclosed
US-20150118209-A1 METHODS OF TREATING AND PREVENTING GRAFT VERSUS HOST DISEASE THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2015-04-30 US disclosed
US-20150118209-A1 METHODS OF TREATING AND PREVENTING GRAFT VERSUS HOST DISEASE THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2015-04-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210121463-A1 METHODS OF TREATING AND PREVENTING GRAFT VERSUS HOST DISEASE BLK, DCK, CILK1 ITK 28/4885LCK 65/4885TXK 9/4885
US-20150118222-A1 TREATMENT USING BRUTON'S TYROSINE KINASE INHIBITORS AND IMMUNOTHERAPY BTK, LCK, LYN ITK 97/4885LCK 2/4885TXK 108/4885
US-20230340412-A1 Expansion Of Peripheral Blood Lymphocytes (PBLS) From Peripheral Blood LTK, LIFR, PBK ITK 372/4885LCK 24/4885TXK 1842/4885
US-20150118209-A1 METHODS OF TREATING AND PREVENTING GRAFT VERSUS HOST DISEASE BLK, DCK, CILK1 ITK 28/4885LCK 65/4885TXK 9/4885
US-20210177854-A1 METHODS OF TREATING AND PREVENTING ALLOANTIBODY DRIVEN CHRONIC GRAFT VERSUS HOST DISEASE FCGR3B, BTK, IGLV6-57 ITK 748/4885LCK 278/4885TXK 475/4885
US-20230165898-A1 EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES FROM LIQUID TUMORS AND THERAPEUTIC USES THEROF CD47, LTK, PBK ITK 1196/4885LCK 61/4885TXK 2215/4885
US-20220133795-A1 Expansion of Tumor Infiltrating Lymphocytes From Liquid Tumors and Therapeutic Uses Thereof PBK, LTK, CD47 ITK 770/4885LCK 55/4885TXK 1644/4885
US-20230100137-A1 METHODS OF TREATING AND PREVENTING ALLOANTIBODY DRIVEN CHRONIC GRAFT VERSUS HOST DISEASE FCGR3B, BTK, IGLV6-57 ITK 748/4885LCK 278/4885TXK 475/4885
US-20150141438-A1 METHODS FOR DELAYING OR PREVENTING THE ONSET OF TYPE 1 DIABETES IAPP, IRS1, CD22 ITK 1418/4885LCK 197/4885TXK 1246/4885
US-20220118011-A1 PROCESSES FOR PRODUCTION OF TUMOR INFILTRATING LYMPHOCYTES AND USES OF SAME IN IMMUNOTHERAPY ICOS, PBK, IL2 ITK 83/4885LCK 12/4885TXK 1150/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.