Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 6/20 | 0.38 |
| ▸ | USP14 | P54578 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | BRD2 | P25440 | 2/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12797222 | 0.90 | BRD4 (0.38) | HSP90AA1HSP90AB1BRD4USP14TSHR | |
| SCHEMBL1667700 | 0.88 | BRD4 (0.36) | HSP90AA1HSP90AB1BRD4USP14TSHR | |
| SCHEMBL1667699 | 0.88 | BRD4 (0.36) | HSP90AA1HSP90AB1BRD4USP14TSHR | |
| SCHEMBL1075535 | 0.84 | ESR1 (0.39) | BRD4TSHRCYP3A4CYP2C9BRD2 | |
| SCHEMBL30386550 | 0.84 | ESR1 (0.39) | BRD4TSHRCYP3A4CYP2C9BRD2 | |
| SCHEMBL1667702 | 0.84 | BRD4 (0.36) | BRD4USP14TSHRCYP3A4CYP2C9 | |
| SCHEMBL1668109 | 0.80 | BRD4 (0.38) | BRD4USP14TSHRCYP3A4CYP2C9 | |
| SCHEMBL1667668 | 0.80 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1USP14CYP2C9CYP2C19 | |
| SCHEMBL1667681 | 0.79 | BRD4 (0.37) | BRD4TSHRCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1667684 | 0.79 | BRD4 (0.37) | BRD4TSHRCYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042474-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | claimed |
| WO-2011042474-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |
| WO-2011042474-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |