Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.34 |
| ▸ | PIM1 | P11309 | 5/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.34 |
| ▸ | USP14 | P54578 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667699 | 1.00 | BRD4 (0.36) | BRD4NTRK1PIM1CHEK1CDK2 | |
| SCHEMBL1667693 | 0.88 | HSP90AA1 (0.39) | BRD4USP14HSP90AA1HSP90AB1CYP1A2 | |
| SCHEMBL12797222 | 0.88 | BRD4 (0.38) | BRD4USP14HSP90AA1HSP90AB1CYP1A2 | |
| SCHEMBL1670150 | 0.85 | BRD4 (0.35) | BRD4NTRK1PIM1CHEK1CDK2 | |
| SCHEMBL1670148 | 0.85 | BRD4 (0.35) | BRD4NTRK1PIM1CHEK1CDK2 | |
| SCHEMBL1077420 | 0.85 | ESR1 (0.38) | BRD4CYP1A2CYP3A4HSD17B10ALOX15 | |
| SCHEMBL1077417 | 0.85 | ESR1 (0.38) | BRD4CYP1A2CYP3A4HSD17B10ALOX15 | |
| SCHEMBL1670089 | 0.84 | ESR1 (0.34) | BRD4NTRK1PIM1CHEK1CDK2 | |
| SCHEMBL1670091 | 0.84 | ESR1 (0.34) | BRD4NTRK1PIM1CHEK1CDK2 | |
| SCHEMBL1667584 | 0.83 | BRD4 (0.33) | BRD4KMT2AESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042474-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | claimed |
| WO-2011042474-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |