Sugi Predict

Sugi Predict / Compounds / SCHEMBL166802

SCHEMBL166802

SCHEMBL166802

COC(=O)c1cc(Br)c(C)cc1OC

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 3/20 0.50
▸ KDM4E B2RXH2 5/20 0.47
▸ LCK P06239 1/20 0.44
▸ FYN P06241 1/20 0.44
▸ POLB P06746 3/20 0.44
▸ HTT P42858 1/20 0.43
▸ TSHR P16473 2/20 0.42
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ KMT2A Q03164 1/20 0.41
▸ SOS1 Q07889 1/20 0.41
▸ ALDH1A1 P00352 3/20 0.41
▸ MAPT P10636 2/20 0.41
▸ LMNA P02545 2/20 0.41
▸ TDP1 Q9NUW8 1/20 0.41
▸ HSD17B10 Q99714 2/20 0.41
▸ USP2 O75604 1/20 0.41
▸ HPGD P15428 2/20 0.40
▸ RECQL P46063 1/20 0.40
▸ CYP1A2 P05177 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22134879 0.93 GAA (0.50) GAAKDM4ELCKFYNPOLB
Ammonia Solution, Strong SCHEMBL22116619 0.91 GAA (0.49) GAAKDM4ELCKFYNPOLB
SCHEMBL18920679 0.86 KDM4E (0.47) GAAKDM4ELCKFYNPOLB
SCHEMBL1919374 0.85 LCK (0.61) KDM4ELCKFYNPOLBTSHR
SCHEMBL383036 0.85 GAA (0.53) GAAKDM4ELCKFYNPOLB
SCHEMBL28934520 0.85 MAPT (0.45) GAAKDM4EHTTTSHRSMN1; SMN2
SCHEMBL5154161 0.85 SOS1 (0.45) GAAKDM4ETSHRKMT2ASOS1
SCHEMBL167967 0.85 POLB (0.51) GAAKDM4EPOLBHTTSMN1; SMN2
SCHEMBL17560071 0.83 TDP1 (0.50) GAAKDM4EPOLBHTTTSHR
SCHEMBL6781993 0.83 KDM4E (0.56) GAAKDM4EPOLBHTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115260180-B Triazole condensed ring derivative, pharmaceutical composition, preparation method and application thereof 长春金赛药业有限责任公司 2024-05-28 — — CN disclosed
CN-116348453-A Heteroaromatic carboxamide compounds and uses thereof 烨辉医药科技(上海)有限公司 2023-06-27 — — CN disclosed
WO-2022228302-A1 HETEROAROMATIC CARBOXAMIDE COMPOUNDS AND ITS USE BIONOVA PHARMACEUTICALS (SHANGHAI) LIMITED (CN) 2022-11-03 — — WO disclosed
CN-115260180-A Triazole fused ring containing derivative, pharmaceutical composition, preparation method and application thereof 长春金赛药业有限责任公司 2022-11-01 — — CN disclosed
EP-3568128-B1 HSP90B N-TERMINAL ISOFORM-SELECTIVE INHIBITORS UNIV KANSAS (US) 2022-07-06 — — EP disclosed
EP-3568128-B1 HSP90B N-TERMINAL ISOFORM-SELECTIVE INHIBITORS UNIV KANSAS (US) 2022-07-06 — — EP disclosed
US-10927076-B2 HSP90B N-terminal isoform-selective inhibitors UNIVERSITY OF KANSAS (US) 2021-02-23 — — US disclosed
EP-3568128-A1 HSP90B N-TERMINAL ISOFORM-SELECTIVE INHIBITORS The University of Kansas (US) 2019-11-20 — — EP disclosed
US-20190337894-A1 HSP90B N-TERMINAL ISOFORM-SELECTIVE INHIBITORS UNIVERSITY OF KANSAS 2019-11-07 — — US disclosed
WO-2018132769-A1 HSP90B N-TERMINAL ISOFORM-SELECTIVE INHIBITORS UNIVERSITY OF KANSAS (US) 2018-07-19 — — WO disclosed
US-20080119490-A1 Viral Polymerase Inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-05-22 — — US disclosed
US-7323470-B2 Viral polymerase inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-01-29 — — US disclosed
US-7323470-B2 Viral polymerase inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-01-29 — — US disclosed
US-20070142380-A1 Viral Polymerase Inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-06-21 — — US disclosed
US-20070142380-A1 Viral Polymerase Inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-06-21 — — US disclosed
US-7223785-B2 Viral polymerase inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-05-29 — — US disclosed
US-7223785-B2 Viral polymerase inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-05-29 — — US disclosed
EP-1636200-A2 INHIBITORS OF PAPILLOMA VIRUS Boehringer Ingelheim International GmbH (DE) 2006-03-22 — — EP disclosed
US-20050014791-A1 Inhibitors of papilloma virus BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2005-01-20 — — US disclosed
WO-2004108673-A2 INHIBITORS OF PAPILLOMA VIRUS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2004-12-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050014791-A1 Inhibitors of papilloma virus TPD52L2, ZC3HAV1, CCNE2 GAA 3887/4885KDM4E 770/4885LCK 3751/4885
US-20190337894-A1 HSP90B N-TERMINAL ISOFORM-SELECTIVE INHIBITORS HSP90AB1, HSP90AB2P, HSP90B1 GAA 2900/4885KDM4E 3915/4885LCK 2876/4885
US-10927076-B2 HSP90B N-terminal isoform-selective inhibitors HSP90AB1, HSP90AB2P, HSP90B1 GAA 2900/4885KDM4E 3915/4885LCK 2876/4885
US-20070142380-A1 Viral Polymerase Inhibitors POLM, POLR2H, POLR2A GAA 1079/4885KDM4E 3117/4885LCK 3405/4885
US-20080119490-A1 Viral Polymerase Inhibitors POLM, POLR2H, POLR2A GAA 994/4885KDM4E 3784/4885LCK 3678/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.