Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CFD | P00746 | 1/20 | 0.45 |
| ▸ | CTSA | P10619 | 5/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16680210 | 1.00 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2CFDCTSAMMP1 | |
| SCHEMBL16681008 | 0.92 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2CFDCTSAHPGD | |
| SCHEMBL16681007 | 0.92 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2CFDCTSAHPGD | |
| SCHEMBL16681339 | 0.80 | CTSA (0.45) | ALDH1A1SMN1; SMN2CFDCTSAPRNP | |
| SCHEMBL16681340 | 0.80 | CTSA (0.45) | ALDH1A1SMN1; SMN2CFDCTSAPRNP | |
| SCHEMBL1138843 | 0.79 | HPGD (0.57) | ALDH1A1SMN1; SMN2CTSAHPGDNPSR1 | |
| SCHEMBL16679989 | 0.78 | FFAR1 (0.47) | ALDH1A1SMN1; SMN2CTSAHPGDPRNP | |
| SCHEMBL16679992 | 0.78 | FFAR1 (0.47) | ALDH1A1SMN1; SMN2CTSAHPGDPRNP | |
| SCHEMBL29288506 | 0.77 | FFAR1 (0.46) | ALDH1A1SMN1; SMN2CTSAHPGDPRNP | |
| SCHEMBL29288504 | 0.77 | FFAR1 (0.46) | ALDH1A1SMN1; SMN2CTSAHPGDPRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9452990-B2 | Complement pathway modulators and uses thereof | NOVARTIS AG (CH) | 2016-09-27 | — | — | US | disclosed |
| EP-2864322-B1 | COMPLEMENT PATHWAY MODULATORS AND USES THEREOF | NOVARTIS AG (CH) | 2016-04-27 | — | — | EP | disclosed |
| US-20150126492-A1 | Complement Pathway Modulators and Uses Thereof | NOVARTIS AG (CH) | 2015-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150126492-A1 | Complement Pathway Modulators and Uses Thereof | CFB, CFH, TFPI | ALDH1A1 2221/4885SMN1; SMN2 3356/4885CFD 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.