Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652766 | 0.86 | HCAR3 (0.47) | EGFRL3MBTL1HCAR3WNK1MAPT | |
| SCHEMBL15984934 | 0.84 | EGFR (0.55) | EGFRL3MBTL1HCAR3WNK1MAPT | |
| SCHEMBL12415846 | 0.79 | EGFR (0.51) | EGFRL3MBTL1HCAR3WNK1MAPT | |
| SCHEMBL4063056 | 0.78 | TDP1 (0.68) | EGFRL3MBTL1HCAR3WNK1MAPT | |
| SCHEMBL27697296 | 0.77 | ALDH3A1 (0.46) | EGFRL3MBTL1HCAR3WNK1MAPT | |
| SCHEMBL2338144 | 0.76 | HCAR3 (0.76) | HCAR3MAPTPOLBAKR1B1AKR1C4 | |
| SCHEMBL1668098 | 0.76 | AKR1B1 (0.53) | EGFRL3MBTL1HCAR3WNK1MAPT | |
| SCHEMBL1668253 | 0.76 | AKR1B1 (0.69) | EGFRL3MBTL1WNK1MAPTAKR1B1 | |
| SCHEMBL12591638 | 0.76 | EGFR (0.46) | EGFRL3MBTL1HCAR3WNK1MAPT | |
| SCHEMBL2648562 | 0.76 | HCAR3 (0.76) | HCAR3MAPTPOLBAKR1B1AKR1C4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011047315-A1 | SUBSITITUTED BENZIMIDAZOLES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |