Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.41 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.41 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL5312853 | 0.79 | TSHR (0.60) | CYP2A6TSHRNOTUMHTTSMN1; SMN2 | |
| Methyl Carbamate SCHEMBL9587539 | 0.78 | HSD17B3 (0.44) | CYP2A6TSHRHSD17B3NOTUMHTT | |
| Hydroxyamine SCHEMBL9527686 | 0.77 | TSHR (0.56) | CYP2A6TSHRCES1NOS3NOS1 | |
| Carbamic Acid SCHEMBL2175348 | 0.77 | TSHR (0.57) | CYP2A6TSHRNOTUMHTTSMN1; SMN2 | |
| Carbamic Acid SCHEMBL9011736 | 0.77 | TSHR (0.65) | CYP2A6TSHRNOTUMHTTSMN1; SMN2 | |
| SCHEMBL33555 | 0.76 | — | — | |
| SCHEMBL29351986 | 0.76 | — | — | |
| SCHEMBL4465325 | 0.76 | TSHR (0.71) | CYP2A6TSHRCES1NOS3NOS1 | |
| SCHEMBL34906 | 0.76 | — | — | |
| Acetamide SCHEMBL5312159 | 0.75 | TSHR (0.55) | CYP2A6TSHRHSD17B3NOTUMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9878985-B2 | Benzocyclobutane(thio) carboxamides | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-01-30 | — | — | US | claimed |
| EP-3062617-B1 | BENZOCYCLOBUTANE(THIO) CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2017-12-06 | — | — | EP | claimed |
| US-20160264529-A1 | BENZOCYCLOBUTANE(THIO) CARBOXAMIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-09-15 | — | — | US | claimed |
| EP-3062617-A1 | BENZOCYCLOBUTANE(THIO) CARBOXAMIDES | Bayer CropScience Aktiengesellschaft (DE) | 2016-09-07 | — | — | EP | claimed |
| WO-2015063086-A1 | BENZOCYCLOBUTANE(THIO) CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2015-05-07 | — | — | WO | claimed |
| US-9878985-B2 | Benzocyclobutane(thio) carboxamides | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-01-30 | — | — | US | disclosed |
| US-9878985-B2 | Benzocyclobutane(thio) carboxamides | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-01-30 | — | — | US | disclosed |
| US-9878985-B2 | Benzocyclobutane(thio) carboxamides | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-01-30 | — | — | US | disclosed |
| EP-3062617-B1 | BENZOCYCLOBUTANE(THIO) CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2017-12-06 | — | — | EP | disclosed |
| US-20160264529-A1 | BENZOCYCLOBUTANE(THIO) CARBOXAMIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-09-15 | — | — | US | disclosed |
| US-20160264529-A1 | BENZOCYCLOBUTANE(THIO) CARBOXAMIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-09-15 | — | — | US | disclosed |
| EP-3062617-A1 | BENZOCYCLOBUTANE(THIO) CARBOXAMIDES | Bayer CropScience Aktiengesellschaft (DE) | 2016-09-07 | — | — | EP | disclosed |
| EP-3062617-A1 | BENZOCYCLOBUTANE(THIO) CARBOXAMIDES | Bayer CropScience Aktiengesellschaft (DE) | 2016-09-07 | — | — | EP | disclosed |
| WO-2015063086-A1 | BENZOCYCLOBUTANE(THIO) CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2015-05-07 | — | — | WO | disclosed |
| WO-2015063086-A1 | BENZOCYCLOBUTANE(THIO) CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2015-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264529-A1 | BENZOCYCLOBUTANE(THIO) CARBOXAMIDES | BOLA2; BOLA2B, TREH, BRD8 | CYP2A6 1862/4885TSHR 1840/4885HSD17B3 4611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.