Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 13/20 | 0.65 |
| ▸ | BCHE | P06276 | 8/20 | 0.63 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.63 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | CASP6 | P55212 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13069498 | 0.89 | ACHE (0.69) | ACHEBCHECHRM1EPHX2 | |
| SCHEMBL16667215 | 0.82 | CYP1A2 (0.66) | ACHEBCHEGRIN1GRIN2ATSHR | |
| SCHEMBL18065454 | 0.82 | ACHE (0.82) | ACHEBCHEGRIN1GRIN2ATSHR | |
| SCHEMBL6609348 | 0.81 | MAPT (0.61) | ACHEBCHEGRIN1GRIN2ATSHR | |
| SCHEMBL2126156 | 0.80 | ACHE (0.74) | ACHEBCHEGRIN1GRIN2ATSHR | |
| SCHEMBL9173286 | 0.80 | ACHE (0.46) | ACHEBCHEGRIN1GRIN2ATSHR | |
| SCHEMBL9259427 | 0.80 | ACHE (0.49) | ACHEBCHETSHRCYP1A2POLB | |
| SCHEMBL18038492 | 0.79 | ACHE (0.63) | ACHEBCHEGRIN1GRIN2ATSHR | |
| SCHEMBL29522722 | 0.79 | ACHE (0.66) | ACHEBCHE | |
| SCHEMBL18065461 | 0.79 | ACHE (0.73) | ACHEBCHEGRIN1GRIN2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2714658-B1 | NOVEL HYBRID CHOLINESTERASE INHIBITORS | UNIV WARSZAWSKI (PL) | 2015-04-29 | — | — | EP | disclosed |