Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.46 |
| ▸ | BCHE | P06276 | 4/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9172551 | 0.82 | ACHE (0.45) | ACHEBCHEPOLB | |
| SCHEMBL16684283 | 0.80 | ACHE (0.65) | ACHEBCHEGRIN1GRIN2ATSHR | |
| SCHEMBL9171934 | 0.78 | ACHE (0.47) | ACHEBCHEGRIN1GRIN2AGAA | |
| SCHEMBL9173623 | 0.76 | ACHE (0.60) | ACHEBCHETSHRCYP1A2HTT | |
| SCHEMBL9174523 | 0.76 | KMT2A (0.44) | ACHEBCHEPOLBHTT | |
| SCHEMBL10638182 | 0.75 | KMT2A (0.53) | ACHEBCHEPOLBGAARECQL | |
| SCHEMBL9168192 | 0.74 | ACHE (0.64) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL6609348 | 0.73 | MAPT (0.61) | ACHEBCHEGRIN1GRIN2ATSHR | |
| SCHEMBL10634424 | 0.72 | ACHE (0.48) | ACHEBCHEPOLB | |
| SCHEMBL9171030 | 0.71 | ACHE (0.59) | ACHEBCHECYP1A2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0285018-B1 | Substituted 9-Amino-Spiro [cycloalkyl[b]quinoline-2,1'cycloalkanes], a process and intermediates for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-05-31 | — | — | EP | disclosed |
| US-4855479-A | Substituted 9-amino-spiro(cycloalkyl(B)quinoline-2,1'cycloalkanes | SHUTSKE GREGORY M (US) | 1989-08-08 | — | — | US | disclosed |
| US-4806646-A | Substituted 9-amino-spiro[cycloalkyl[B]quinoline-2,1'cycloalkanes] | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| US-4762841-A | Substituted 9-amino-spiro(cycloalkyl(b)quinoline-2,1'cycloalkanes) | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-08-09 | — | — | US | disclosed |