Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 8/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16695101 | 1.00 | IRAK4 (0.40) | IRAK4NOTUMPDK2ALDH1A1MAPT | |
| SCHEMBL16695084 | 0.91 | GHSR (0.41) | IRAK4NOTUMPDK2ALDH1A1MAPT | |
| SCHEMBL16695566 | 0.90 | NOTUM (0.51) | NOTUM | |
| SCHEMBL21340137 | 0.87 | MAPT (0.43) | NOTUMPDK2ALDH1A1MAPT | |
| SCHEMBL16695388 | 0.81 | NOTUM (0.51) | NOTUM | |
| SCHEMBL16684690 | 0.74 | NOTUM (0.47) | NOTUMPDK2 | |
| SCHEMBL16695100 | 0.74 | NOTUM (0.47) | NOTUMPDK2 | |
| SCHEMBL16695146 | 0.74 | NOTUM (0.47) | NOTUMPDK2 | |
| SCHEMBL16695065 | 0.73 | NOTUM (0.43) | NOTUMPDK2RORC | |
| SCHEMBL16695078 | 0.73 | NOTUM (0.43) | NOTUMPDK2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-A1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BioMarin Pharmaceutical Inc. (US) | 2016-09-07 | — | — | EP | disclosed |
| WO-2015065937-A1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARMACEUTICAL INC. (US) | 2015-05-07 | — | — | WO | disclosed |
| WO-2015065937-A1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARMACEUTICAL INC. (US) | 2015-05-07 | — | — | WO | disclosed |