Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 6/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 6/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL342623 | 0.95 | EP300 (0.35) | HCAR2TDP1 | |
| SCHEMBL8676391 | 0.95 | EP300 (0.35) | HCAR2TDP1 | |
| SCHEMBL342622 | 0.95 | EP300 (0.35) | HCAR2TDP1 | |
| SCHEMBL4016866 | 0.80 | EP300 (0.32) | HCAR2 | |
| SCHEMBL4016868 | 0.80 | EP300 (0.32) | HCAR2 | |
| Maleic Acid SCHEMBL27416819 | 0.75 | HCAR2 (0.50) | HCAR2PLA2G1BATG4BTHRATHRB | |
| SCHEMBL10008914 | 0.75 | EP300 (0.35) | HCAR2CYP1A2TDP1 | |
| SCHEMBL9513413 | 0.73 | EP300 (0.39) | TDP1 | |
| Maleic Acid SCHEMBL11695225 | 0.72 | HCAR2 (0.64) | HCAR2PLA2G1BATG4BTHRATHRB | |
| Fumaric Acid SCHEMBL28133862 | 0.72 | HCAR2 (0.64) | HCAR2PLA2G1BATG4BTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063181-B1 | HYDROPHILIC/HYDROPHOBIC AQUEOUS POLYMER EMULSIONS AND PRODUCTS AND METHODS RELATING THERETO | ALLEGIANCE CORP (US) | 2019-01-02 | — | — | EP | disclosed |
| EP-3063181-A1 | HYDROPHILIC/HYDROPHOBIC AQUEOUS POLYMER EMULSIONS AND PRODUCTS AND METHODS RELATING THERETO | Allegiance Corporation (US) | 2016-09-07 | — | — | EP | disclosed |
| WO-2015066227-A1 | HYDROPHILIC/HYDROPHOBIC AQUEOUS POLYMER EMULSIONS AND PRODUCTS AND METHODS RELATING THERETO | AVERY DENNISON CORPORATION (US) | 2015-05-07 | — | — | WO | disclosed |