Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | EYA2 | O00167 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL2587854 | 0.94 | ALOX15 (0.46) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL28735231 | 0.94 | ALOX15 (0.46) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL5874273 | 0.94 | ALOX15 (0.46) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL29199404 | 0.90 | ALOX15 (0.44) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL7744496 | 0.90 | ALOX15 (0.44) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL7744499 | 0.90 | ALOX15 (0.44) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL3048457 | 0.87 | MAPT (0.41) | ALOX15KDM4EMAPTSMN1; SMN2TSHR | |
| Trolamine SCHEMBL11788795 | 0.87 | MAPT (0.41) | ALOX15KDM4EMAPTSMN1; SMN2TSHR | |
| Trolamine SCHEMBL7699169 | 0.84 | ALOX15 (0.44) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL5875005 | 0.84 | ALOX15 (0.44) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3074488-A1 | HYBRID SOLVENT FORMULATIONS FOR SELECTIVE H2S REMOVAL | Dow Global Technologies LLC (US) | 2016-10-05 | — | — | EP | disclosed |
| EP-3062912-A1 | HYBRID SOLVENT FORMULATIONS FOR TOTAL ORGANIC SULFUR REMOVAL AND TOTAL ACIDIC GAS REMOVAL | Dow Global Technologies LLC (US) | 2016-09-07 | — | — | EP | disclosed |
| WO-2015065842-A1 | HYBRID SOLVENT FORMULATIONS FOR TOTAL ORGANIC SULFUR REMOVAL AND TOTAL ACIDIC GAS REMOVAL | DOW GLOBAL TECHNOLOGIES LLC (US) | 2015-05-07 | — | — | WO | disclosed |
| WO-2015065839-A1 | HYBRID SOLVENT FORMULATIONS FOR SELECTIVE H2S REMOVAL | DOW GLOBLAL TECHNOLOGIES LLC (US) | 2015-05-07 | — | — | WO | disclosed |