Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | EYA2 | O00167 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL28735231 | 1.00 | ALOX15 (0.46) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL5874273 | 1.00 | ALOX15 (0.46) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL29199404 | 0.97 | ALOX15 (0.44) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL7744496 | 0.97 | ALOX15 (0.44) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL7744499 | 0.97 | ALOX15 (0.44) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL16685495 | 0.94 | ALOX15 (0.42) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL5875005 | 0.90 | ALOX15 (0.44) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL7699169 | 0.90 | ALOX15 (0.44) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 | |
| Trolamine SCHEMBL29632739 | 0.89 | MAPT (0.44) | ALOX15KDM4EMAPTSMN1; SMN2TSHR | |
| Trolamine SCHEMBL28167757 | 0.89 | MAPT (0.44) | ALOX15KDM4EMAPTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240138403-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2024-05-02 | — | — | US | claimed |
| US-20230021295-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2023-01-19 | — | — | US | claimed |
| WO-2023278670-A1 | SYNERGISTIC COMBINATIONS FOR REDUCING VOLATILITY OF AUXIN HERBICIDES | ETHOX CHEMICALS, LLC (US) | 2023-01-05 | — | — | WO | claimed |
| CN-114573121-A | Composite corrosion and scale inhibitor suitable for geothermal system | 常州大学 | 2022-06-03 | — | — | CN | claimed |
| EP-0282921-A1 | Liquid, phosphate-free, one phase degreasing agent for aluminium surfaces | Henkel Kommanditgesellschaft auf Aktien (DE) | 1988-09-21 | — | — | EP | claimed |
| US-20240138403-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2024-05-02 | — | — | US | disclosed |
| US-20240027453-A1 | METHOD FOR DETECTION AND QUANTITATIVE MONITORING OF INFECTIONS WITH HERPESVIRUSES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2024-01-25 | — | — | US | disclosed |
| US-20230021295-A1 | Synergistic Combinations for Reducing Volatility of Auxin Herbicides | ETHOX CHEMICALS, LLC | 2023-01-19 | — | — | US | disclosed |
| WO-2023278670-A1 | SYNERGISTIC COMBINATIONS FOR REDUCING VOLATILITY OF AUXIN HERBICIDES | ETHOX CHEMICALS, LLC (US) | 2023-01-05 | — | — | WO | disclosed |
| CN-112426865-B | System for capturing and releasing acid gases | 碳捕获有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-114573121-A | Composite corrosion and scale inhibitor suitable for geothermal system | 常州大学 | 2022-06-03 | — | — | CN | disclosed |
| WO-2022026537-A1 | METHOD FOR DETECTION AND QUANTITATIVE MONITORING OF INFECTIONS WITH HERPESVIRUSES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2022-02-03 | — | — | WO | disclosed |
| WO-1996040265-A1 | STABILIZATION OF POLYNUCLEOTIDE COMPLEXES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-12-19 | — | — | WO | disclosed |
| US-5399681-A | Alkylation with ethyleneimine, rearrangement, bonding to polymer or macromolecule solid support | GESELLSCHAFT FUR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) (DE) | 1995-03-21 | — | — | US | disclosed |
| EP-0247537-B1 | PROCESS FOR THE PREPARATION OF N6-SUBSTITUTED NAD, NADP OR FAD | Gesellschaft für Biotechnologische Forschung mbH (GBF) (DE) | 1991-09-04 | — | — | EP | disclosed |
| US-4844744-A | Liquid, phosphate-free single phase degreasing compositions | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1989-07-04 | — | — | US | disclosed |
| US-4717503-A | QUICKLIME, ALKALI METAL (BI)CARBONATE, FLUIDIZATION, HYDROXY CARBOXYLIC ACID | MITSUBISHI MINING & CO., LTD. (JP) | 1988-01-05 | — | — | US | disclosed |
| EP-0247537-A2 | Process for the preparation of N6-substituted NAD, NADP or FAD | Gesellschaft für Biotechnologische Forschung mbH (GBF) (DE) | 1987-12-02 | — | — | EP | disclosed |
| EP-0103194-B1 | DEMOLITION AGENT FOR BRITTLE MATERIALS | MITSUBISHI MINING & CEMENT CO., LTD. (JP) | 1987-01-14 | — | — | EP | disclosed |
| EP-0103194-A1 | Demolition agent for brittle materials | MITSUBISHI MINING & CEMENT CO., LTD. (JP) | 1984-03-21 | — | — | EP | disclosed |