Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.59 |
| ▸ | MEN1 | O00255 | 7/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30968903 | 1.00 | KDM4E (0.59) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11909835 | 0.78 | KDM4E (0.57) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL27340756 | 0.78 | KDM4E (0.50) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL23207366 | 0.78 | KDM4E (0.50) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9978534 | 0.78 | ADORA2A (0.60) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL16438246 | 0.75 | KDM4E (0.71) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL28318666 | 0.75 | KDM4E (0.56) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL16685892 | 0.75 | KDM4E (0.47) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL498897 | 0.74 | KDM4E (1.00) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11364912 | 0.73 | KDM4E (0.59) | KDM4EMEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260007642-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR PROMOTING NEUROGENESIS AND INHIBITING NERVE CELL DEATH | UNIV CASE WESTERN RESERVE (US) | 2026-01-08 | — | — | US | disclosed |
| US-20250295640-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS | CASE WESTERN RESERVE UNIVERSITY | 2025-09-25 | — | — | US | disclosed |
| CN-118059093-A | Inhibitors of short chain dehydrogenase activity for the treatment of fibrosis | 卡斯西部储备大学 | 2024-05-24 | — | — | CN | disclosed |
| US-20240100026-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR PROMOTING NEUROGENESIS AND INHIBITING NERVE CELL DEATH | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2024-03-28 | — | — | US | disclosed |
| US-20230285402-A1 | Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity | UNIV TEXAS (US) | 2023-09-14 | — | — | US | disclosed |
| US-20230285402-A1 | Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity | UNIV TEXAS (US) | 2023-09-14 | — | — | US | disclosed |
| US-20230285402-A1 | Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity | UNIV TEXAS (US) | 2023-09-14 | — | — | US | disclosed |
| US-20230136730-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-04 | — | — | US | disclosed |
| US-20230136730-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-04 | — | — | US | disclosed |
| US-20230136730-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-04 | — | — | US | disclosed |
| US-9789116-B2 | Compositions and methods of modulating short-chain dehydrogenase activity | CASE WESTERN RESERVE UNIVERSITY (US) | 2017-10-17 | — | — | US | disclosed |
| US-9789116-B2 | Compositions and methods of modulating short-chain dehydrogenase activity | CASE WESTERN RESERVE UNIVERSITY (US) | 2017-10-17 | — | — | US | disclosed |
| US-20170173028-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-22 | — | — | US | disclosed |
| US-20170173028-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-22 | — | — | US | disclosed |
| US-20170173028-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2017-06-22 | — | — | US | disclosed |
| WO-2016144958-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS | CASE WESTERN RESERVE UNIVERSITY (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144958-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS | CASE WESTERN RESERVE UNIVERSITY (US) | 2016-09-15 | — | — | WO | disclosed |
| EP-3057973-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | Case Western Reserve University (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015065716-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | CASE WESTERN RESERVE UNIVERSITY (US) | 2015-05-07 | — | — | WO | disclosed |
| WO-2015065716-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | CASE WESTERN RESERVE UNIVERSITY (US) | 2015-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230136730-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | HPGD, GCDH, HPGDS | KDM4E 3506/4885MEN1 4461/4885KMT2A 3903/4885 |
| US-20240100026-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR PROMOTING NEUROGENESIS AND INHIBITING NERVE CELL DEATH | HPGD, GCDH, DCX | KDM4E 3121/4885MEN1 4843/4885KMT2A 3226/4885 |
| US-20230285402-A1 | Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity | HPGD, GCDH, HPGDS | KDM4E 3506/4885MEN1 4461/4885KMT2A 3903/4885 |
| US-20250295640-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS | GCDH, HPGD, UGDH | KDM4E 3226/4885MEN1 4619/4885KMT2A 3603/4885 |
| US-20260007642-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR PROMOTING NEUROGENESIS AND INHIBITING NERVE CELL DEATH | PTGDR, HPGD, PTGDR2 | KDM4E 3195/4885MEN1 4874/4885KMT2A 3082/4885 |
| US-20170173028-A1 | COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY | HPGD, GCDH, HPGDS | KDM4E 3506/4885MEN1 4461/4885KMT2A 3903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.