Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14181983 | 0.88 | HDAC1 (0.46) | MAPK1HDAC6KDM4ENAMPT | |
| SCHEMBL18726788 | 0.88 | POLB (0.49) | POLBKDM4ENAMPTLMNAMAPT | |
| SCHEMBL10014111 | 0.88 | HCAR3 (0.52) | KDM4EALDH1A1NAMPTSMN1; SMN2MAPT | |
| SCHEMBL12589232 | 0.88 | KDM4E (0.50) | POLBKDM4EALDH1A1NAMPTLMNA | |
| SCHEMBL13349240 | 0.87 | POLB (0.48) | POLBKDM4ENAMPTLMNAMAPT | |
| SCHEMBL17035833 | 0.87 | L3MBTL1 (0.52) | KDM4EALDH1A1SMN1; SMN2MAPTCA2 | |
| SCHEMBL16710823 | 0.85 | KDM4E (0.47) | KDM4ENAMPTMAPT | |
| SCHEMBL12588565 | 0.84 | KDM4E (0.43) | POLBKDM4EALDH1A1NAMPTLMNA | |
| SCHEMBL14418819 | 0.81 | FOLH1 (0.47) | HDAC6POLBKDM4EFOLH1NAMPT | |
| SCHEMBL16688446 | 0.81 | MAPK1 (0.61) | MAPK1HDAC6CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150125904-A1 | PROBE INCORPORATION MEDIATED BY ENZYMES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-05-07 | — | — | US | disclosed |
| US-20150125904-A1 | PROBE INCORPORATION MEDIATED BY ENZYMES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-05-07 | — | — | US | disclosed |